Rizzi Roberto, Bearzi Claudia, Mauretti Arianna, Bernardini Sergio, Cannata Stefano, Gargioli Cesare
IRCCS MultiMedica, Milan, Italy ; Cell Biology and Neurobiology Institute, National Research Council of Italy, Rome, Italy.
Muscles Ligaments Tendons J. 2012 Oct 16;2(3):230-4. Print 2012 Jul.
Stem cells and regenerative medicine have obtained a remarkable consent from the scientific community for their promising ability to recover aged, injured and diseased tissue. However, despite the noteworthy potential, hurdles currently hinder their use and clinical application: cell survival, immune response, tissue engraftment and efficient differentiation. Hence a new interdisciplinary scientific approach, such as tissue engineering, is going deep attempts to mimic neo-tissue-genesis as well as stem cell engraftment amelioration. Skeletal muscle tissue engineering represents a great potentiality in medicine for muscle regeneration exploiting new generation injectable hydrogel as scaffold supporting progenitor/stem cells for muscle differentiation reconstructing the natural skeletal muscle tissue architecture influenced by matrix mechanical and physical property and by a dynamic environment.
干细胞与再生医学因其在恢复老化、受损和患病组织方面的显著潜力而获得了科学界的高度认可。然而，尽管具有显著潜力，但目前仍存在障碍阻碍其应用和临床实践，这些障碍包括细胞存活、免疫反应、组织植入和有效分化。因此，一种新的跨学科科学方法，如组织工程，正在深入尝试模拟新组织生成以及改善干细胞植入。骨骼肌组织工程利用新一代可注射水凝胶作为支架，支持祖细胞/干细胞进行肌肉分化，重建受基质机械和物理特性以及动态环境影响的天然骨骼肌组织结构，在医学上具有巨大的肌肉再生潜力。
