Christian Lisa M, Iams Jay, Porter Kyle, Leblebicioglu Binnaz
Department of Psychiatry, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA,
Ann Behav Med. 2013 Dec;46(3):295-309. doi: 10.1007/s12160-013-9521-7.
Biobehavioral correlates of self-rated health in pregnancy are largely unknown.
The goals of this study were to examine, in pregnant women, associations of self-rated health with (1) demographics, objective health status, health behaviors, and psychological factors, and (2) serum inflammatory markers.
In the second trimester of pregnancy, 101 women provided a blood sample, completed measures of psychosocial stress, health status, and health behaviors, and received a comprehensive periodontal examination.
The following independently predicted poorer self-rated health: (1) greater psychological stress, (2) greater objective health diagnoses, (3) higher body mass index, and (4) past smoking (versus never smoking). Poorer self-rated health was associated with higher serum interleukin-1β (p = 0.02) and marginally higher macrophage migration inhibitory factor (p = 0.06). These relationships were not fully accounted for by behavioral/psychological factors.
This study provides novel data regarding factors influencing subjective ratings of health and the association of self-rated health with serum inflammatory markers in pregnant women.
孕期自评健康的生物行为相关性很大程度上尚不明确。
本研究的目的是在孕妇中检验自评健康与以下因素的关联:(1)人口统计学特征、客观健康状况、健康行为和心理因素;(2)血清炎症标志物。
在妊娠中期,101名女性提供了血液样本,完成了心理社会压力、健康状况和健康行为的测量,并接受了全面的牙周检查。
以下因素独立预测了较差的自评健康:(1)更大的心理压力;(2)更多的客观健康诊断;(3)更高的体重指数;(4)既往吸烟(相对于从不吸烟)。较差的自评健康与更高的血清白细胞介素-1β(p = 0.02)以及略高的巨噬细胞移动抑制因子(p = 0.06)相关。行为/心理因素并未完全解释这些关系。
本研究提供了关于影响健康主观评分的因素以及孕妇自评健康与血清炎症标志物之间关联的新数据。