• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Rgg 相关 SHP 信号肽介导链球菌中的串扰。

Rgg-associated SHP signaling peptides mediate cross-talk in Streptococci.

机构信息

INRA, UMR1319 MICALIS, Jouy en Josas, France ; AgroParistech, UMR MICALIS, Jouy en Josas, France.

出版信息

PLoS One. 2013 Jun 11;8(6):e66042. doi: 10.1371/journal.pone.0066042. Print 2013.

DOI:10.1371/journal.pone.0066042
PMID:23776602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3679016/
Abstract

We described a quorum-sensing mechanism in the streptococci genus involving a short hydrophobic peptide (SHP), which acts as a pheromone, and a transcriptional regulator belonging to the Rgg family. The shp/rgg genes, found in nearly all streptococcal genomes and in several copies in some, have been classified into three groups. We used a genetic approach to evaluate the functionality of the SHP/Rgg quorum-sensing mechanism, encoded by three selected shp/rgg loci, in pathogenic and non-pathogenic streptococci. We characterized the mature form of each SHP pheromone by mass-spectrometry. We produced synthetic peptides corresponding to these mature forms, and used them to study functional complementation and cross-talk between these different SHP/Rgg systems. We demonstrate that a SHP pheromone of one system can influence the activity of a different system. Interestingly, this does not seem to be dependent on the SHP/Rgg group and cross-talk between pathogenic and non-pathogenic streptococci is observed.

摘要

我们描述了一种涉及短疏水性肽（SHP）作为信息素和属于 Rgg 家族的转录调节因子的链球菌属中的群体感应机制。shp/rgg 基因存在于几乎所有链球菌基因组中，在一些基因组中存在多个拷贝，已被分为三组。我们使用遗传方法评估了三个选定的 shp/rgg 基因座编码的 SHP/Rgg 群体感应机制在致病性和非致病性链球菌中的功能。我们通过质谱法对每个 SHP 信息素的成熟形式进行了表征。我们合成了与这些成熟形式相对应的肽，并使用它们来研究这些不同的 SHP/Rgg 系统之间的功能互补和串扰。我们证明了一个系统的 SHP 信息素可以影响不同系统的活性。有趣的是，这似乎并不依赖于 SHP/Rgg 组，并且观察到致病性和非致病性链球菌之间的串扰。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e16/3679016/295128250cce/pone.0066042.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e16/3679016/c891c546df33/pone.0066042.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e16/3679016/e6de3dcb9a75/pone.0066042.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e16/3679016/1878dbda166d/pone.0066042.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e16/3679016/295128250cce/pone.0066042.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e16/3679016/c891c546df33/pone.0066042.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e16/3679016/e6de3dcb9a75/pone.0066042.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e16/3679016/1878dbda166d/pone.0066042.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e16/3679016/295128250cce/pone.0066042.g004.jpg

相似文献

1
Rgg-associated SHP signaling peptides mediate cross-talk in Streptococci.Rgg 相关 SHP 信号肽介导链球菌中的串扰。
PLoS One. 2013 Jun 11;8(6):e66042. doi: 10.1371/journal.pone.0066042. Print 2013.
2
Export of Rgg Quorum Sensing Peptides is Mediated by the PptAB ABC Transporter in Strain LMD-9.Rgg群体感应肽的输出由菌株LMD-9中的PptAB ABC转运蛋白介导。
Genes (Basel). 2020 Sep 19;11(9):1096. doi: 10.3390/genes11091096.
3
Multiple length peptide-pheromone variants produced by Streptococcus pyogenes directly bind Rgg proteins to confer transcriptional regulation.化脓性链球菌产生的多种长度的肽-信息素变体直接结合Rgg蛋白以实现转录调控。
J Biol Chem. 2014 Aug 8;289(32):22427-36. doi: 10.1074/jbc.M114.583989. Epub 2014 Jun 23.
4
Identification of Quorum-Sensing Inhibitors Disrupting Signaling between Rgg and Short Hydrophobic Peptides in Streptococci.鉴定破坏链球菌中Rgg与短疏水肽之间信号传导的群体感应抑制剂。
mBio. 2015 May 12;6(3):e00393-15. doi: 10.1128/mBio.00393-15.
5
Rgg proteins associated with internalized small hydrophobic peptides: a new quorum-sensing mechanism in streptococci.与内化的小疏水性肽相关的 Rgg 蛋白：链球菌中的一种新的群体感应机制。
Mol Microbiol. 2011 May;80(4):1102-19. doi: 10.1111/j.1365-2958.2011.07633.x. Epub 2011 Mar 30.
6
Characterization of a Signaling System in Streptococcus mitis That Mediates Interspecies Communication with Streptococcus pneumoniae.解析链球菌属信号系统介导肺炎链球菌种间通讯
Appl Environ Microbiol. 2019 Jan 9;85(2). doi: 10.1128/AEM.02297-18. Print 2019 Jan 15.
7
Structure-function studies of Rgg binding to pheromones and target promoters reveal a model of transcription factor interplay.Rgg 与信息素和靶启动子结合的结构-功能研究揭示了转录因子相互作用的模型。
Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24494-24502. doi: 10.1073/pnas.2008427117. Epub 2020 Sep 9.
8
Identification of a Quorum Sensing System Regulating Capsule Polysaccharide Production and Biofilm Formation in .鉴定一种群体感应系统，调控 中荚膜多糖产生和生物膜形成。
Front Cell Infect Microbiol. 2019 Apr 18;9:121. doi: 10.3389/fcimb.2019.00121. eCollection 2019.
9
RovS and its associated signaling peptide form a cell-to-cell communication system required for Streptococcus agalactiae pathogenesis.RovS及其相关信号肽形成了无乳链球菌致病所需的细胞间通讯系统。
mBio. 2015 Jan 20;6(1):e02306-14. doi: 10.1128/mBio.02306-14.
10
Two group A streptococcal peptide pheromones act through opposing Rgg regulators to control biofilm development.两组 A 族链球菌肽信息素通过相反的 Rgg 调节剂作用控制生物膜的发展。
PLoS Pathog. 2011 Aug;7(8):e1002190. doi: 10.1371/journal.ppat.1002190. Epub 2011 Aug 4.

引用本文的文献

1
Genome Mining for New Enzyme Chemistry.用于新酶化学的基因组挖掘
ACS Catal. 2024 Mar 12;14(7):4536-4553. doi: 10.1021/acscatal.3c06322. eCollection 2024 Apr 5.
2
Bacterial quorum sensing orchestrates longitudinal interactions to shape microbiota assembly.细菌群体感应协调纵向相互作用，塑造微生物组装配。
Microbiome. 2023 Nov 6;11(1):241. doi: 10.1186/s40168-023-01699-4.
3
Streptococcal peptides and their roles in host-microbe interactions.链球菌肽及其在宿主-微生物相互作用中的作用。

本文引用的文献

1
Extracellular life cycle of ComS, the competence-stimulating peptide of Streptococcus thermophilus.热链球菌感受态刺激肽 ComS 的细胞外生活周期。
J Bacteriol. 2013 Apr;195(8):1845-55. doi: 10.1128/JB.02196-12. Epub 2013 Feb 8.
2
Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective.衰减金黄色葡萄球菌毒力基因调控：药物化学视角。
J Med Chem. 2013 Feb 28;56(4):1389-404. doi: 10.1021/jm3014635. Epub 2013 Jan 22.
3
Antagonistic Rgg regulators mediate quorum sensing via competitive DNA binding in Streptococcus pyogenes.
Front Cell Infect Microbiol. 2023 Oct 16;13:1282622. doi: 10.3389/fcimb.2023.1282622. eCollection 2023.
4
Targeting Peptide-Based Quorum Sensing Systems for the Treatment of Gram-Positive Bacterial Infections.靶向基于肽的群体感应系统治疗革兰氏阳性细菌感染
Pept Sci (Hoboken). 2023 Mar;115(2). doi: 10.1002/pep2.24298. Epub 2022 Nov 12.
5
Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound.变形链球菌群体感应调控胰酶素（一种新型 Ras-RiPP 类抗菌化合物）的产生。
mBio. 2021 Mar 16;12(2):e02688-20. doi: 10.1128/mBio.02688-20.
6
The pneumococcal social network.肺炎球菌社交网络。
PLoS Pathog. 2020 Oct 29;16(10):e1008931. doi: 10.1371/journal.ppat.1008931. eCollection 2020 Oct.
7
Export of Rgg Quorum Sensing Peptides is Mediated by the PptAB ABC Transporter in Strain LMD-9.Rgg群体感应肽的输出由菌株LMD-9中的PptAB ABC转运蛋白介导。
Genes (Basel). 2020 Sep 19;11(9):1096. doi: 10.3390/genes11091096.
8
Structure-function studies of Rgg binding to pheromones and target promoters reveal a model of transcription factor interplay.Rgg 与信息素和靶启动子结合的结构-功能研究揭示了转录因子相互作用的模型。
Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24494-24502. doi: 10.1073/pnas.2008427117. Epub 2020 Sep 9.
9
Multi-omics Approach Reveals How Yeast Extract Peptides Shape Streptococcus thermophilus Metabolism.多组学方法揭示酵母提取物肽如何塑造嗜热链球菌的代谢。
Appl Environ Microbiol. 2020 Oct 28;86(22). doi: 10.1128/AEM.01446-20.
10
A Bacterial Tower of Babel: Quorum-Sensing Signaling Diversity and Its Evolution.细菌的巴别塔：群体感应信号多样性及其进化。
Annu Rev Microbiol. 2020 Sep 8;74:587-606. doi: 10.1146/annurev-micro-012220-063740. Epub 2020 Jul 17.
抗 Rgg 调节蛋白通过与 DNA 的竞争结合介导酿脓链球菌中的群体感应。
mBio. 2013 Jan 2;3(6):e00333-12. doi: 10.1128/mBio.00333-12.
4
The Human Microbiome Project: a community resource for the healthy human microbiome.人类微生物组计划：健康人类微生物组的社区资源。
PLoS Biol. 2012;10(8):e1001377. doi: 10.1371/journal.pbio.1001377. Epub 2012 Aug 14.
5
The quorum sensing diversity within and between ecotypes of Bacillus subtilis.枯草芽孢杆菌生态型内和生态型间群体感应的多样性。
Environ Microbiol. 2012 Jun;14(6):1378-89. doi: 10.1111/j.1462-2920.2012.02717.x. Epub 2012 Mar 6.
6
Recent progress in Bacillus subtilis sporulation.枯草芽孢杆菌芽孢形成的最新进展。
FEMS Microbiol Rev. 2012 Jan;36(1):131-48. doi: 10.1111/j.1574-6976.2011.00310.x. Epub 2011 Oct 25.
7
The rgg0182 gene encodes a transcriptional regulator required for the full Streptococcus thermophilus LMG18311 thermal adaptation.rgg0182 基因编码一种转录调节因子，该因子是嗜热链球菌 LMG18311 完全热适应所必需的。
BMC Microbiol. 2011 Oct 7;11:223. doi: 10.1186/1471-2180-11-223.
8
Two group A streptococcal peptide pheromones act through opposing Rgg regulators to control biofilm development.两组 A 族链球菌肽信息素通过相反的 Rgg 调节剂作用控制生物膜的发展。
PLoS Pathog. 2011 Aug;7(8):e1002190. doi: 10.1371/journal.ppat.1002190. Epub 2011 Aug 4.
9
Rgg proteins associated with internalized small hydrophobic peptides: a new quorum-sensing mechanism in streptococci.与内化的小疏水性肽相关的 Rgg 蛋白：链球菌中的一种新的群体感应机制。
Mol Microbiol. 2011 May;80(4):1102-19. doi: 10.1111/j.1365-2958.2011.07633.x. Epub 2011 Mar 30.
10
The human oral microbiome.人类口腔微生物组。
J Bacteriol. 2010 Oct;192(19):5002-17. doi: 10.1128/JB.00542-10. Epub 2010 Jul 23.