Nalbantoglu Burcin, Donma Metin M, Ozdilek Burcu, Karasu Erkut, Nalbantoglu Aysin
Department of Pediatrics, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.
Iran J Pediatr. 2013 Jun;23(3):276-80.
This study was designed to determine the current age-related hepatitis A virus (HAV) seroprevalance, vaccination status of children and to evaluate the epidemiological shift in HAV serostatus living in Tekirdağ, which is located in Thrace region, the European part of Turkey.
Children 6 months-12 years of age with simple health problems were included. Blood samples were studied for HAV IgM and IgG collectively. A questionnaire addressing several characteristics of subjects was administered to obtain basic descriptive data on HAV epidemiology. Vaccination status of the children was recorded according to the immunization cards.
The overall anti-HAV IgM and anti-HAV IgG prevalance in children aged 6 months - 12 years was 3.3% and 25.4% respectively. Maximum hepatitis A IgM positivity was in the 7-12 years age group 4.8% (n= 12; P<0.001) and maximum hepatitis A IgG positivity in the same age group was 34% (n = 85; P<0.001). HAV vaccination rate among patients aged more than 2 years was 11.03%. HAV IgG seroprevalance was higher in children of low monthly income families (36.1%, n = 78; P<0.001) than in the intermediate (17%, n = 31) and high income families (11.1%, n = 6).
These results indicate a shift in Hepatitis A seroprevalance when compared with the previous studies. As HAV infection in childhood is decreasing, the pool of susceptible adolescents and young adults is increasing. Introduction of hepatitis A vaccination into the national immunization schedule of Turkey should be considered.
本研究旨在确定当前与年龄相关的甲型肝炎病毒（HAV）血清流行率、儿童的疫苗接种状况，并评估居住在土耳其欧洲部分色雷斯地区的泰基尔达的人群中HAV血清状态的流行病学变化。
纳入有简单健康问题的6个月至12岁儿童。对血液样本进行HAV IgM和IgG的综合检测。发放一份涉及受试者若干特征的问卷，以获取有关HAV流行病学的基本描述性数据。根据免疫接种卡记录儿童的疫苗接种状况。
6个月至12岁儿童中抗-HAV IgM和抗-HAV IgG的总体流行率分别为3.3%和25.4%。甲型肝炎IgM阳性率最高的是7至12岁年龄组，为4.8%（n = 12；P<0.001），同一年龄组甲型肝炎IgG阳性率最高为34%（n = 85；P<0.001）。2岁以上患者的HAV疫苗接种率为11.03%。月收入低的家庭的儿童中HAV IgG血清流行率（36.1%，n = 78；P<0.001）高于中等收入家庭（17%，n = 31）和高收入家庭（11.1%，n = 6）。
这些结果表明，与之前的研究相比，甲型肝炎血清流行率发生了变化。由于儿童期HAV感染在减少，易感青少年和年轻人的数量在增加。应考虑将甲型肝炎疫苗纳入土耳其的国家免疫规划。
