Department of Parasitology and Mycology, Mazandaran University of Medical Sciences, Sari, Iran.
Eur Rev Med Pharmacol Sci. 2013 Jul;17(13):1760-5.
Echinococcosis infection is caused in humans by the larval stage of cestodes belonging to the genus Echinococcus. Hydatid cyst cured by percutaneous aspiration, infusion of scolicidal agents with reaspiration or surgery. Many scolicidal agents have been used for inactivation of the cyst's content, but most of them are not safe due to their unanticipated side effects. In the present study, the scolicidal effect of methanolic extract of Sambucus (S.) ebulus fruit is investigated.
Protoscolices were aseptically aspirated from sheep livers having hydatid cysts. Four concentrations (1, 10, 50 and 100 mg ml-1) of S. ebulus extract were used for 5, 10, 30 and 60 min. Viability of protoscolices was confirmed by 0.1% Eosin staining.
The results of our study indicated that methanolic extract of S. ebulus fruit showed a high scolicidal activity in vitro (p < 0.0001).
Methanolic extract of S. ebulus showed high scolicidal activity in vitro. It might be used as a scolicidal cause in the surgical treatment of the hydatid cyst. However, further research on the in vivo efficacy of S. ebulus extract and its potential side effects is recommended.
人类感染包虫病是由属于细粒棘球绦虫属的绦虫幼虫引起的。包虫囊肿通过经皮抽吸、注入杀囊剂后再抽吸或手术治愈。已经使用了许多杀囊剂来灭活囊液，但由于其意想不到的副作用，大多数杀囊剂并不安全。本研究旨在研究桑（S.）ebulus 果实甲醇提取物的杀囊作用。
从患有包虫囊肿的绵羊肝脏中无菌抽吸原头蚴。使用 4 种浓度（1、10、50 和 100 mg ml-1）的 S.ebulus 提取物处理 5、10、30 和 60 分钟。通过 0.1%伊红染色确认原头蚴的活力。
我们的研究结果表明，桑（S.）ebulus 果实的甲醇提取物在体外具有很高的杀囊活性（p < 0.0001）。
桑（S.）ebulus 果实的甲醇提取物在体外具有很高的杀囊活性。它可能在包虫囊肿的手术治疗中用作杀囊剂。然而，建议进一步研究 S.ebulus 提取物的体内疗效及其潜在的副作用。
