Department of Chemistry, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, 3A1, Jupiter, FL 33458 (USA).
Angew Chem Int Ed Engl. 2013 Sep 16;52(38):10010-3. doi: 10.1002/anie.201301639. Epub 2013 Aug 1.
Won't let you go! A strategy is described to design small molecules that react with their cellular RNA targets. This approach not only improves the activity of compounds targeting RNA in cell culture by a factor of about 2500 but also enables cell-wide profiling of its RNA targets.
不让你走！描述了一种设计小分子与细胞内 RNA 靶标反应的策略。这种方法不仅将化合物靶向细胞内 RNA 的活性提高了约 2500 倍，而且还能够对其 RNA 靶标进行全细胞分析。
