Nazarbayev University Research and Innovation System, Nazarbayev University, Astana 010000, Kazakhstan.
Int J Mol Sci. 2013 Aug 6;14(8):16258-79. doi: 10.3390/ijms140816258.
Oxidative stress and inflammation play major roles in the pathogenesis of coronary heart disease including myocardial infarction (MI). The pathological progression following MI is very complex and involves a number of cell populations including cells localized within the heart, as well as cells recruited from the circulation and other tissues that participate in inflammatory and reparative processes. These cells, with their secretory factors, have pleiotropic effects that depend on the stage of inflammation and regeneration. Excessive inflammation leads to enlargement of the infarction site, pathological remodeling and eventually, heart dysfunction. Stem cell therapy represents a unique and innovative approach to ameliorate oxidative stress and inflammation caused by ischemic heart disease. Consequently, it is crucial to understand the crosstalk between stem cells and other cells involved in post-MI cardiac tissue repair, especially immune cells, in order to harness the beneficial effects of the immune response following MI and further improve stem cell-mediated cardiac regeneration. This paper reviews the recent findings on the role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair following ischemic heart disease, particularly acute MI and focuses specifically on mesenchymal, muscle and blood-vessel-derived stem cells due to their antioxidant and immunomodulatory properties.
氧化应激和炎症在包括心肌梗死（MI）在内的冠心病发病机制中起主要作用。MI 后的病理进展非常复杂，涉及许多细胞群体，包括位于心脏内的细胞，以及从循环和其他组织招募的参与炎症和修复过程的细胞。这些细胞及其分泌因子具有依赖于炎症和再生阶段的多效性效应。过度的炎症会导致梗死部位扩大、病理性重构，最终导致心脏功能障碍。干细胞治疗代表了一种改善缺血性心脏病引起的氧化应激和炎症的独特而创新的方法。因此，了解干细胞与参与 MI 后心脏组织修复的其他细胞（特别是免疫细胞）之间的相互作用至关重要，以便利用 MI 后免疫反应的有益作用，并进一步改善干细胞介导的心脏再生。本文综述了近年来关于抗氧化和免疫调节在缺血性心脏病后多能干细胞介导的心脏修复中的作用的研究进展，特别是急性 MI，并特别关注间充质、肌肉和血管来源的干细胞，因为它们具有抗氧化和免疫调节特性。
