University of Michigan, Department of Psychiatry and Addiction Research Center, 4250 Plymouth Road, Ann Arbor, MI 48109, United States.
Brain Lang. 2013 Sep;126(3):314-26. doi: 10.1016/j.bandl.2013.06.006. Epub 2013 Aug 7.
According to the cue-based parsing approach (Lewis, Vasishth, & Van Dyke, 2006), sentence comprehension difficulty derives from interference from material that partially matches syntactic and semantic retrieval cues. In a 2 (low vs. high semantic interference)×2 (low vs. high syntactic interference) fMRI study, greater activation was observed in left BA44/45 for high versus low syntactic interference conditions following sentences and in left BA45/47 for high versus low semantic interference conditions following comprehension questions. A conjunction analysis showed BA45 associated with both types of interference, while BA47 was associated with only semantic interference. Greater activation was also observed in the left STG in the high interference conditions. Importantly, the results for the LIFG could not be attributed to greater working memory capacity demands for high interference conditions. The results favor a fractionation of the LIFG wherein BA45 is associated with post-retrieval selection and BA47 with controlled retrieval of semantic information.
根据基于提示的解析方法（Lewis、Vasishth 和 Van Dyke，2006），句子理解的难度源于与句法和语义检索提示部分匹配的材料的干扰。在一项 2（低语义干扰与高语义干扰）×2（低句法干扰与高句法干扰）的 fMRI 研究中，在句子后观察到左侧 BA44/45 在高句法干扰条件下比低句法干扰条件下的激活更大，在理解问题后，在左侧 BA45/47 中观察到高语义干扰条件下比低语义干扰条件下的激活更大。联合分析显示 BA45 与两种干扰类型相关，而 BA47 仅与语义干扰相关。在高干扰条件下，左侧 STG 也观察到了更大的激活。重要的是，左 LIFG 的结果不能归因于高干扰条件下对工作记忆容量的更高需求。结果支持 LIFG 的细分，其中 BA45 与检索后选择相关，BA47 与语义信息的受控检索相关。
