用于血管移植物组织工程的静电纺丝支架。
Electrospun scaffolds for tissue engineering of vascular grafts.
机构信息
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Acta Biomater. 2014 Jan;10(1):11-25. doi: 10.1016/j.actbio.2013.08.022. Epub 2013 Aug 22.
Abstract
There is a growing demand for off-the-shelf tissue engineered vascular grafts (TEVGs) for the replacement or bypass of damaged arteries in various cardiovascular diseases. Scaffolds from the decellularized tissue skeletons to biopolymers and biodegradable synthetic polymers have been used for fabricating TEVGs. However, several issues have not yet been resolved, which include the inability to mimic the mechanical properties of native tissues, and the ability for long-term patency and growth required for in vivo function. Electrospinning is a popular technique for the production of scaffolds that has the potential to address these issues. However, its application to human TEVGs has not yet been achieved. This review provides an overview of tubular scaffolds that have been prepared by electrospinning with potential for TEVG applications.
摘要
对于替代或绕过各种心血管疾病中受损动脉的现成组织工程血管移植物（TEVG）的需求日益增长。脱细胞组织骨架的支架、生物聚合物和可生物降解的合成聚合物已被用于制造 TEVG。然而，一些问题尚未得到解决，包括无法模拟天然组织的机械性能，以及体内功能所需的长期通畅性和生长能力。静电纺丝是一种生产支架的流行技术，具有解决这些问题的潜力。然而，它在人体 TEVG 中的应用尚未实现。本文综述了通过静电纺丝制备的管状支架在 TEVG 应用方面的潜力。
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