Department of Biomedical Engineering, Department of Chemistry, The Fitzpatrick Institute for Photonics, Duke University, Durham, NC 27708, USA.
Nanoscale. 2013 Nov 7;5(21):10127-40. doi: 10.1039/c3nr03633b. Epub 2013 Sep 20.
This article provides an overview of the development and applications of plasmonics-active nanoprobes in our laboratory for chemical sensing, medical diagnostics and therapy. Molecular Sentinel nanoprobes provide a unique tool for DNA/RNA biomarker detection both in a homogeneous solution or on a chip platform for medical diagnostics. The possibility of combining spectral selectivity and high sensitivity of the surface-enhanced Raman scattering (SERS) process with the inherent molecular specificity of nanoprobes provides an important multiplex diagnostic modality. Gold nanostars can provide an excellent multi-modality platform, combining two-photon luminescence with photothermal therapy as well as Raman imaging with photodynamic therapy. Several examples of optical detection using SERS and photonics-based treatments are presented to illustrate the usefulness and potential of the plasmonic nanoprobes for theranostics, which seamlessly combines diagnostics and therapy.
本文概述了我们实验室在化学传感、医学诊断和治疗中开发和应用等离子体激元活性纳米探针的情况。分子哨兵纳米探针为在均相溶液或芯片平台上进行 DNA/RNA 生物标志物检测提供了独特的工具，可用于医学诊断。将表面增强拉曼散射（SERS）过程的光谱选择性和高灵敏度与纳米探针固有的分子特异性相结合的可能性为多模式诊断提供了一种重要的方法。金纳米星可以提供一个极好的多模态平台，将双光子发光与光热治疗以及拉曼成像与光动力治疗结合起来。本文介绍了几个使用 SERS 和基于光子的治疗方法进行光学检测的例子，以说明等离子体纳米探针在治疗诊断中的实用性和潜力，它将诊断和治疗无缝结合在一起。
