Liu Yang, Yuan Hsiangkuo, Kersey Farrell R, Register Janna K, Parrott Matthew C, Vo-Dinh Tuan
Fitzpatrick Institute for Photonics, Duke University, Durham, NC 27708, USA.
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Sensors (Basel). 2015 Feb 5;15(2):3706-20. doi: 10.3390/s150203706.
Gold nanostars (AuNSs) are unique systems that can provide a novel multifunctional nanoplatform for molecular sensing and diagnostics. The plasmonic absorption band of AuNSs can be tuned to the near infrared spectral range, often referred to as the "tissue optical window", where light exhibits minimal absorption and deep penetration in tissue. AuNSs have been applied for detecting disease biomarkers and for biomedical imaging using multi-modality methods including surface-enhanced Raman scattering (SERS), two-photon photoluminescence (TPL), magnetic resonance imaging (MRI), positron emission tomography (PET), and X-ray computer tomography (CT) imaging. In this paper, we provide an overview of the recent development of plasmonic AuNSs in our laboratory for biomedical applications and highlight their potential for future translational medicine as a multifunctional nanoplatform.
金纳米星（AuNSs）是独特的体系，可为分子传感和诊断提供新型多功能纳米平台。AuNSs的等离子体吸收带可被调谐至近红外光谱范围，该范围通常被称为“组织光学窗口”，在此光在组织中的吸收最小且穿透深度大。AuNSs已被用于检测疾病生物标志物，并通过包括表面增强拉曼散射（SERS）、双光子光致发光（TPL）、磁共振成像（MRI）、正电子发射断层扫描（PET）和X射线计算机断层扫描（CT）成像在内的多模态方法用于生物医学成像。在本文中，我们概述了我们实验室中用于生物医学应用的等离子体AuNSs的最新进展，并强调了其作为多功能纳米平台在未来转化医学中的潜力。
