Xing Ruijun, Liu Gang, Zhu Jinghan, Hou Yanglong, Chen Xiaoyuan
Department of Materials Science and Engineering College of Engineering, Peking University, Beijing, 100871, China.
Pharm Res. 2014 Jun;31(6):1377-89. doi: 10.1007/s11095-013-1205-2. Epub 2013 Sep 25.
Gene therapy is becoming a promising strategy to treat various kinds of genetic and acquired diseases. However, the development of safe, efficient, and targetable gene delivery systems remains a major challenge in gene therapy. The unique material characteristics of magnetic nanoparticles (MNPs), including high surface area, facile surface modification, controllable size, and excellent magnetic properties, make them promising candidates for gene delivery. The engineered MNPs with modifiable functional surfaces and bioactive cores can result in several advantageous diagnostic and therapeutic properties including enhanced magnetic resonance imaging (MRI) signal intensity, long permeation and retention in the circulatory system, specific delivery of therapeutic genes to target sites. In this review, the updated research on the preparation and surface modification of MNPs for gene delivery is summarized.
基因治疗正成为治疗各种遗传疾病和后天性疾病的一种有前景的策略。然而，开发安全、高效且具有靶向性的基因递送系统仍然是基因治疗中的一项重大挑战。磁性纳米颗粒（MNPs）独特的材料特性，包括高比表面积、易于表面修饰、尺寸可控以及优异的磁性，使其成为基因递送的有潜力候选者。具有可修饰功能表面和生物活性核心的工程化MNPs可产生多种有利的诊断和治疗特性，包括增强磁共振成像（MRI）信号强度、在循环系统中的长循环和滞留、将治疗性基因特异性递送至靶位点。在本综述中，总结了用于基因递送的MNPs制备和表面修饰的最新研究。
