用真菌壳聚糖作为一种新型生物分子对细粒棘球绦虫进行体外处理。
In vitro treatments of Echinococcus granulosus with fungal chitosan, as a novel biomolecule.
作者信息
Rahimi-Esboei Bahman, Fakhar Mahdi, Chabra Aroona, Hosseini Mahboobeh
机构信息
Department of Parasitology, School of Public health, Tehran University of Medical Sciences, Iran.
出版信息
Asian Pac J Trop Biomed. 2013 Oct;3(10):811-5. doi: 10.1016/S2221-1691(13)60160-4. Epub 2013 Sep 4.
Abstract
OBJECTIVE
To determined the antiparasitic activity of the isolated chitosan from Penicillium viridicatum, Penicillium aurantiogriseum and commercial chitosan against protoscolicidal of hydatid cysts were determined.
METHODS
After isolating chitosan from fungal cell walls, four concentrations (50, 100, 200, 400 μg/mL) of each type of prepared chitosan and commercial chitosan were used for 10, 30, 60, and 180 min, respectively.
RESULTS
Among different type of chitosan, commercial chitosan with the highest degree of deacetylation showed high scolicidal activity in vitro. Fungal chitosan could be recommended, as good as commercial chitosan, for hydatic cysts control.
CONCLUSIONS
It seems to be a good alternative to synthetic and chemical scolicidal.
摘要
目的
测定从绿青霉、橙灰青霉分离得到的壳聚糖以及市售壳聚糖对包虫囊肿原头蚴的抗寄生虫活性。
方法
从真菌细胞壁分离出壳聚糖后，将每种制备的壳聚糖和市售壳聚糖的四种浓度（50、100、200、400μg/mL）分别作用10、30、60和180分钟。
结果
在不同类型的壳聚糖中，脱乙酰度最高的市售壳聚糖在体外表现出较高的杀原头蚴活性。真菌壳聚糖在控制包虫囊肿方面与市售壳聚糖一样，可以被推荐使用。
结论
它似乎是合成和化学杀原头蚴剂的一个很好的替代品。
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2
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Acta Trop. 2013 Aug;127(2):136-42. doi: 10.1016/j.actatropica.2013.04.008. Epub 2013 Apr 28.
3
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9
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