早年经历中国饥荒与成年后患贫血症的风险
Exposure to the Chinese famine in early life and the risk of anaemia in adulthood.
作者信息
Shi Zumin, Zhang Cuilin, Zhou Minghao, Zhen Shiqi, Taylor Anne W
机构信息
Department of Nutrition and Foodborne Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
出版信息
BMC Public Health. 2013 Oct 1;13:904. doi: 10.1186/1471-2458-13-904.
BACKGROUND
Famine exposure during the early stage of life is related to a number of adulthood diseases. The objective of this study was to examine the association of early life exposure to the famine in China (1959-1961) with the risk of anaemia in adulthood.
METHODS
We used the data of 2007 adults born between 1954 and 1964 in Jiangsu province from the 2002 Chinese National Nutrition and Health Survey. Anaemia was defined as haemoglobin concentration <12 g/dl in women and <13 g/dl in men.
RESULTS
Prevalence of anaemia in adulthood in nonexposed, fetal-exposed, early-childhood, mid-childhood, and late-childhood exposed to famine groups were 26.0%, 33.8%, 28.1%, 28.2% and 29.7%, respectively. Overall, fetal-exposed to famine was associated with 37% increased risk of anaemia as compared with those non-exposed after adjusting for income, education, place of residence, smoking, alcohol drinking, job, hypertension and BMI; relative risk (95% confidence interval) (RR (95% CI)) was 1.37 (1.09, 1.71). In general, this association appeared to be stronger among men, those who were currently overweight or obese, or those of lower educational levels. Corresponding RR (95% CI) was 1.87 (1.21-2.87), 1.75 (1.20-2.56), and 2.07 (1.37-3.12), respectively.
CONCLUSIONS
Fetal exposure to the Chinese famine was associated with an increased risk of anaemia in adulthood.
背景
生命早期经历饥荒与多种成年期疾病有关。本研究的目的是探讨中国1959 - 1961年饥荒的早期生命暴露与成年期贫血风险之间的关联。
方法
我们使用了2002年中国国家营养与健康调查中江苏省1954年至1964年出生的2007名成年人的数据。贫血定义为女性血红蛋白浓度<12 g/dl，男性血红蛋白浓度<13 g/dl。
结果
未暴露组、胎儿期暴露组、幼儿期暴露组、童年中期暴露组和童年晚期暴露组成年期贫血患病率分别为26.0%、33.8%、28.1%、28.2%和29.7%。总体而言，在调整收入、教育程度、居住地点、吸烟、饮酒、工作、高血压和体重指数后，与未暴露者相比，胎儿期暴露于饥荒的人群患贫血的风险增加了37%；相对风险（95%置信区间）（RR（95%CI））为1.37（1.09，1.71）。一般来说，这种关联在男性、目前超重或肥胖者或教育水平较低者中似乎更强。相应的RR（95%CI）分别为1.87（1.21 - 2.87）、1.75（1.20 - 2.56）和2.07（1.37 - 3.12）。
结论
胎儿期暴露于中国饥荒与成年期贫血风险增加有关。
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