Biochemistry Department, University of Geneva, 1211 Geneva 4, Switzerland.
Cold Spring Harb Perspect Biol. 2013 Oct 1;5(10):a016816. doi: 10.1101/cshperspect.a016816.
Intracellular organelles, including endosomes, show differences not only in protein but also in lipid composition. It is becoming clear from the work of many laboratories that the mechanisms necessary to achieve such lipid segregation can operate at very different levels, including the membrane biophysical properties, the interactions with other lipids and proteins, and the turnover rates or distribution of metabolic enzymes. In turn, lipids can directly influence the organelle membrane properties by changing biophysical parameters and by recruiting partner effector proteins involved in protein sorting and membrane dynamics. In this review, we will discuss how lipids are sorted in endosomal membranes and how they impact on endosome functions.
细胞内细胞器，包括内体，不仅在蛋白质组成上存在差异，在脂质组成上也存在差异。许多实验室的工作表明，实现这种脂质分隔的必要机制可以在非常不同的水平上发挥作用，包括膜的物理特性、与其他脂质和蛋白质的相互作用以及代谢酶的周转率或分布。反过来，脂质可以通过改变生物物理参数和招募参与蛋白质分选和膜动力学的伴侣效应蛋白，直接影响细胞器膜的性质。在这篇综述中，我们将讨论脂质如何在内体膜中进行分拣，以及它们如何影响内体的功能。
