Qi Wenjuan, Li Rui, Ma Teng, Li Jiawen, Kirk Shung K, Zhou Qifa, Chen Zhongping
Beckman Laser Institute, University of California Irvine, 1002 Health Sciences Road East, Irvine, California 92612, USA ; Department of Chemical Engineering and Materials Science, University of California Irvine, Irvine, California 92697, USA.
Appl Phys Lett. 2013 Sep 2;103(10):103704. doi: 10.1063/1.4820252. Epub 2013 Sep 6.
We report on a resonant acoustic radiation force optical coherence elastography (ARF-OCE) technique that uses mechanical resonant frequency to characterize and identify tissues of different types. The linear dependency of the resonant frequency on the square root of Young's modulus was validated on silicone phantoms. Both the frequency response spectrum and the 3D imaging results from the agar phantoms with hard inclusions confirmed the feasibility of deploying the resonant frequency as a mechanical contrast for tissue imaging. Furthermore, the results of resonant ARF-OCE imaging of a post-mortem human coronary artery with atherosclerosis demonstrate the potential of the resonant ARF-OCE as a non-invasive method for imaging and characterizing vulnerable plaques.
我们报告了一种共振声辐射力光学相干弹性成像（ARF-OCE）技术，该技术利用机械共振频率来表征和识别不同类型的组织。在硅酮仿体上验证了共振频率与杨氏模量平方根的线性相关性。含有硬内含物的琼脂仿体的频率响应谱和三维成像结果均证实了将共振频率用作组织成像的机械对比度的可行性。此外，对患有动脉粥样硬化的人死后冠状动脉进行共振ARF-OCE成像的结果表明，共振ARF-OCE作为一种用于成像和表征易损斑块的非侵入性方法具有潜力。
