Qu Yueqiao, Ma Teng, He Youmin, Zhu Jiang, Dai Cuixia, Yu Mingyue, Huang Shenghai, Lu Fan, Shung K Kirk, Zhou Qifa, Chen Zhongping
Department of Biomedical Engineering, the Edwards Life Sciences Center for Advanced Cardiovascular Technology, and Beckman Laser Institute, University of California, Irvine, Irvine, CA 92697 USA.
NIH Ultrasonic Transducer Resource Center and the Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
IEEE J Sel Top Quantum Electron. 2016 May-Jun;22(3). doi: 10.1109/JSTQE.2016.2524618. Epub 2016 Feb 8.
We report on a real-time acoustic radiation force optical coherence elastography (ARF-OCE) system to map the relative elasticity of corneal tissue. A modulated ARF is used as excitation to vibrate the cornea while OCE serves as detection of tissue response. To show feasibility of detecting mechanical contrast using this method, we performed tissue-equivalent agarose phantom studies with inclusions of a different stiffness. We obtained 3-D elastograms of a healthy cornea and a highly cross-linked cornea. Finally we induced a stiffness change on a small portion of a cornea and observed the differences in displacement.
我们报告了一种用于绘制角膜组织相对弹性图谱的实时声辐射力光学相干弹性成像（ARF-OCE）系统。调制后的声辐射力用作激发来振动角膜，而光学相干弹性成像则用于检测组织响应。为了证明使用该方法检测机械对比度的可行性，我们对包含不同硬度内含物的组织等效琼脂糖模型进行了研究。我们获得了健康角膜和高度交联角膜的三维弹性图。最后，我们在一小部分角膜上诱导了硬度变化，并观察了位移差异。
