Colombo Caroline Macoris, de Macedo Rafael Michel, Fernandes-Silva Miguel Morita, Caporal Alexandra Moro, Stinghen Andréa Emilia, Costantini Costantino Roberto, Baena Cristina Pellegrino, Guarita-Souza Luiz Cesar, Faria-Neto José Rocha
Einstein (Sao Paulo). 2013 Jul-Sep;11(3):324-30. doi: 10.1590/s1679-45082013000300011.
To evaluate whether a short-term moderate intensity exercise program could change inflammatory parameters, and improve different components of metabolic syndrome in sedentary patients.
Sixteen patients completed the 12-week program of supervised exercise, which consisted of a 40 to 50 minutes of walking, 3 times a week, reaching 50 to 60% of the heart rate reserve. The parameters evaluated before and after intervention were waist circumference, systolic and diastolic blood pressure, triglycerides, LDL cholesterol, HDL cholesterol, total cholesterol, C-reactive protein and interleukin 8.
There was a significant reduction in waist circumference (102.1±7.5cm to 100.8±7.4cm; p=0.03) and in body mass index (29.7±3.2kg/m² versus 29.3±3.5kg/m²; p=0.03). Systolic blood pressure dropped from 141±18 to 129±13mmHg and diastolic from 79±12 to 71±10mmHg (with p<0.05 for both). No changes were observed on total cholesterol, LDL cholesterol and triglycerides, although HDL cholesterol levels improved, from 45.5±6.0 to 49.5±9.8mg/dL (p=0.02). There was a trend toward reduction of C-reactive protein (8.3%; p=0.07) and interleukin 8 levels (17.4%; p=0.058). The improvement in cardiovascular capacity was demonstrated by an increase of 13% in estimated volume of oxygen (p<0.001).
Benefits of aerobic exercise of moderate intensity were seen within only 12 weeks of training in sedentary patients with metabolic syndrome. Considering the easy self-applicability and proven metabolic effects, an exercise program could be a first approach to sedentary patients with metabolic syndrome.
评估短期中等强度运动计划是否能改变炎症参数，并改善久坐不动的患者代谢综合征的不同组成部分。
16名患者完成了为期12周的有监督的运动计划，该计划包括每周3次、每次40至50分钟的步行，达到心率储备的50%至60%。干预前后评估的参数有腰围、收缩压和舒张压、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、总胆固醇、C反应蛋白和白细胞介素8。
腰围显著减小（从102.1±7.5厘米降至100.8±7.4厘米；p = 0.03），体重指数也显著降低（从29.7±3.2千克/平方米降至29.3±3.5千克/平方米；p = 0.03）。收缩压从141±18降至129±13毫米汞柱，舒张压从79±12降至71±10毫米汞柱（两者p均<0.05）。总胆固醇、低密度脂蛋白胆固醇和甘油三酯未见变化，不过高密度脂蛋白胆固醇水平有所改善，从45.5±6.0毫克/分升升至49.5±9.8毫克/分升（p = 0.02）。C反应蛋白有降低趋势（8.3%；p = 0.07），白细胞介素8水平有降低趋势（17.4%；p = 0.058）。估计的氧气量增加了13%，证明心血管能力得到改善（p<0.001）。
对于患有代谢综合征的久坐不动的患者，仅经过12周的训练就能看到中等强度有氧运动的益处。考虑到其易于自我实施且已证实的代谢效果，运动计划可能是患有代谢综合征的久坐不动患者的首选方法。
