Gazi University, School of Physical Education and Sports, Department of Exercise Physiology , Ankara, Turkey.
J Sports Sci Med. 2007 Dec 1;6(4):417-22. eCollection 2007.
The purpose of this study was to determine the changes of oxidative response and exercise-induced muscle damage after two different resistance exercise protocols. Whether training with low or high intensity resistance programs cause alterations in the activities of lipid peroxidation, nitric oxide (NOx), and creatine kinase (CK) activity in human plasma was investigated. Twenty untrained males participated into this study. Ten of the subjects performed high intensity resistance (HR) exercise circuit and the rest of them performed low intensity resistance (LR) exercise circuit of 4 different exercises as a single bout. Venous blood samples were drawn pre-exercise, immediately after the exercise, and at the 6(th), 24(th), 48(th) and the72(nd) hours of post-exercise. Samples were analyzed for markers of muscle damage (CK), lipid peroxidation (MDA) and NOx. NOx production increased in HR group (p < 0.05). The MDA response to the two different resistance exercise protocol in this study caused a significant increase between pre and post-exercise values in both groups (p < 0.05). Also, there was a significant difference in the MDA level between the two groups in post-exercise values (p < 0.05) and higher values were observed in HR group. CK activities showed a significant increase in all post exercise values (p < 0.05) of both groups but there were no difference between HR and LR groups. These findings support that high intensity resistance exercise induces free radical production more than low intensity resistance exercise program. Key pointsHigh intensity resistance exercise caused increases in NOx, MDA and CK levels.Light intensity resistance exercises increased MDA and CK levels but did not affect NOx levels.Damage arose during resistance exercises may be related to the level of resistance applied.
本研究旨在确定两种不同的抗阻运动方案后氧化反应和运动诱导的肌肉损伤的变化。研究了低强度和高强度抗阻训练方案是否会改变人血浆中脂质过氧化、一氧化氮（NOx）和肌酸激酶（CK）活性的变化。20 名未经训练的男性参与了这项研究。其中 10 名受试者进行高强度抗阻（HR）运动循环，其余受试者进行 4 种不同运动的低强度抗阻（LR）运动循环。在运动前、运动后即刻以及运动后 6（第）、24（第）、48（第）和 72（第）小时抽取静脉血样。对肌肉损伤标志物（CK）、脂质过氧化（MDA）和 NOx 进行分析。HR 组的 NOx 产生增加（p < 0.05）。在这两种不同的抗阻运动方案中，MDA 对运动的反应在两组中均导致运动前后值显著增加（p < 0.05）。此外，两组在运动后值的 MDA 水平存在显著差异（p < 0.05），HR 组的 MDA 水平更高。CK 活性在两组的所有运动后值均显著增加（p < 0.05），但 HR 和 LR 组之间没有差异。这些发现支持高强度抗阻运动比低强度抗阻运动方案更能诱导自由基的产生。关键点高强度抗阻运动导致 NOx、MDA 和 CK 水平升高。低强度抗阻运动增加 MDA 和 CK 水平，但不影响 NOx 水平。抗阻运动引起的损伤可能与所施加的阻力水平有关。
