0.3%阿达帕林用于治疗女性痤疮。
Adapalene 0.3% for the treatment of acne in women.
作者信息
Berson Diane, Alexis Andrew
机构信息
Weill Medical College of Cornell University, New York, New York;
出版信息
J Clin Aesthet Dermatol. 2013 Oct;6(10):32-5.
SETTING
Acne vulgaris is characterized by comedones, papules, pustules, and secondary lesions. Historically, it has been considered a disease primarily affecting adolescents, but recent reports over the past three decades suggest an increasing prevalence in adults, particularly women. Adapalene was developed for the topical treatment of acne. Adapalene (6-[3-(l-adamantyl)-4-methoxyphenyl]-2-naphthoic acid) is a synthetic naphthoic acid derivative with potent retinoid activity including the reversal of the abnormal follicular keratinization and microcomedo formation and decreasing inflammatory lesions. Design/objective: In this analysis, data from two studies comparing adapalene gel 0.3% to vehicle gel were combined and evaluated for change in lesion counts and Investigator's Global Assessment of success rates in adult female subjects ages 18 to 41 years with acne vulgaris.
RESULTS
The results showed a statistically significant difference favoring adapalene gel 0.3% for reduction in total lesion count at Week 12 (P=0.045). Additionally, median reduction for inflammatory lesions (-61%) and noninflammatory lesions (-51%) also favored adapalene. In addition, adapalene gel, 0.3% was well tolerated with similar tolerability compared to adapalene gel 0.1%; the most common treatment-related adverse events were skin discomfort and dry skin. There were no reported serious adverse events in any group.
CONCLUSION
In this subgroup analysis, adapalene gel 0.3% proved effective and well tolerated in adult women with acne vulgaris.
背景
寻常痤疮的特征为粉刺、丘疹、脓疱及继发性损害。从历史上看，该病一直被认为主要影响青少年，但过去三十年的近期报告显示，其在成年人尤其是女性中的患病率呈上升趋势。阿达帕林被开发用于痤疮的局部治疗。阿达帕林（6-[3-(1-金刚烷基)-4-甲氧基苯基]-2-萘甲酸）是一种具有强大类视黄醇活性的合成萘甲酸衍生物，包括逆转异常的毛囊角化和微粉刺形成以及减少炎性损害。设计/目的：在本分析中，将两项比较0.3%阿达帕林凝胶与赋形剂凝胶的研究数据合并，并评估18至41岁患有寻常痤疮的成年女性受试者的皮损计数变化及研究者对成功率的整体评估。
结果
结果显示，在第12周时，0.3%阿达帕林凝胶在减少总皮损计数方面具有统计学显著差异（P=0.045）。此外，炎性损害（-61%）和非炎性损害（-51%）的中位数减少也有利于阿达帕林。此外，0.3%阿达帕林凝胶耐受性良好，与0.1%阿达帕林凝胶的耐受性相似；最常见的与治疗相关的不良事件是皮肤不适和皮肤干燥。任何组均未报告严重不良事件。
结论
在该亚组分析中，0.3%阿达帕林凝胶在患有寻常痤疮的成年女性中被证明有效且耐受性良好。
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