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本文引用的文献

1
NSR from Streptococcus agalactiae confers resistance against nisin and is encoded by a conserved nsr operon.无乳链球菌的 NSR 赋予了对乳链菌肽的抗性，由一个保守的 nsr 操纵子编码。
Biol Chem. 2013 Nov;394(11):1543-9. doi: 10.1515/hsz-2013-0167.
2
Lantibiotics from Geobacillus thermodenitrificans.来自嗜热脱硫杆菌的羊毛硫抗生素。
Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5241-6. doi: 10.1073/pnas.1116815109. Epub 2012 Mar 19.
3
Discovery, biosynthesis, and engineering of lantipeptides.拉尼肽的发现、生物合成和工程改造。
Annu Rev Biochem. 2012;81:479-505. doi: 10.1146/annurev-biochem-060110-113521. Epub 2012 Mar 8.
4
Lipid II and other bactoprenol-bound cell wall precursors as drug targets.脂质II和其他细菌萜醇结合的细胞壁前体作为药物靶点。
Curr Opin Investig Drugs. 2010 Feb;11(2):157-64.
5
Insights into the mode of action of the two-peptide lantibiotic haloduracin.洞悉两肽类羊毛硫抗生素卤虫素的作用模式。
ACS Chem Biol. 2009 Oct 16;4(10):865-74. doi: 10.1021/cb900194x.
6
Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis.脂磷壁酸的D-丙氨酰化增加和隔膜增厚是乳酸乳球菌对乳链菌肽抗性机制的主要决定因素。
Microbiology (Reading). 2008 Jun;154(Pt 6):1755-1762. doi: 10.1099/mic.0.2007/015412-0.
7
The generation of nisin variants with enhanced activity against specific gram-positive pathogens.生成对特定革兰氏阳性病原体具有增强活性的乳链菌肽变体。
Mol Microbiol. 2008 Jul;69(1):218-30. doi: 10.1111/j.1365-2958.2008.06279.x. Epub 2008 May 9.
8
Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin.模式羊毛硫抗生素乳链菌肽的生物合成、免疫、调控、作用方式及工程改造
Cell Mol Life Sci. 2008 Feb;65(3):455-76. doi: 10.1007/s00018-007-7171-2.
9
Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation.通过对A环和B环进行诱变以及C端截短来剖析和调控乳链菌肽的四种不同活性。
Appl Environ Microbiol. 2007 Sep;73(18):5809-16. doi: 10.1128/AEM.01104-07. Epub 2007 Jul 27.
10
An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II.针对脂质II的羊毛硫抗生素肽的另一种杀菌作用机制。
Science. 2006 Sep 15;313(5793):1636-7. doi: 10.1126/science.1129818.

Mode of action and structure-activity relationship studies of geobacillin I.

作者信息

Garg Neha, Oman Trent J, Andrew Wang Tsung-Shing, De Gonzalo Chantal V Garcia, Walker Suzanne, van der Donk Wilfred A

机构信息

Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Department of Chemistry, Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

出版信息

J Antibiot (Tokyo). 2014 Jan;67(1):133-6. doi: 10.1038/ja.2013.112. Epub 2013 Oct 30.

DOI:10.1038/ja.2013.112
PMID:24169799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4004768/
Abstract
摘要