Division of Metabolism and Functionality Research, Korea Food Research Institute, Seongnam 463-746, Korea ; Division of Applied Life Science, Department of Food Science and Technology, Institue of Agriculture and Life Science, Gyeongsang National University, Jinju 660-701, Korea.
J Ginseng Res. 2013 Jul;37(3):371-8. doi: 10.5142/jgr.2013.37.371.
Serum and liver metabolites in rats fed red ginseng (RG) were analyzed by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. The mass data were analyzed by partial least squares-discriminant analysis (PLS-DA) to discriminate between control and RG groups and identify metabolites contributing to this discrimination. The RG group was clearly separated from the control group on PLS-DA scores plot for serum samples, but not liver samples. The major metabolites contributing to the discrimination included lipid metabolites (lysophosphatidylcholine, acyl-carnitine, and sphingosine), isoleucine, nicotinamide, and corticosterone in the serum; the blood levels of all but isoleucine were reduced by RG administration. Not all metabolites were positively correlated with the health benefits of RG. However, the blood levels of lysophosphatidylcholine, which stimulate various diseases, and long-chain acylcarnitines and corticosterone, which activate the stress response, were reduced by RG, suggesting long-term RG might relieve stress and prevent physiological and biological problems.
采用超高效液相色谱-四极杆飞行时间质谱法分析大鼠灌胃红参后的血清和肝脏代谢物。采用偏最小二乘判别分析（PLS-DA）对对照和红参组进行区分，并鉴定出导致这种区分的代谢物。血清样本的 PLS-DA 得分图中，红参组与对照组明显分离，但肝脏样本没有。对区分有主要贡献的代谢物包括血清中的脂质代谢物（溶血磷脂酰胆碱、酰基辅酶 A 和神经鞘氨醇）、异亮氨酸、烟酰胺和皮质酮；除异亮氨酸外，所有代谢物的血液水平均因红参给药而降低。并非所有代谢物都与红参的健康益处呈正相关。然而，溶血磷脂酰胆碱（可刺激各种疾病）、长链酰基辅酶 A 和皮质酮（激活应激反应）的血液水平降低，表明长期服用红参可能有助于缓解压力，预防生理和生物问题。
