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生物活性植物提取物对耐甲氧西林表皮葡萄球菌的体外抗菌及抗生素耐药性修饰作用

In Vitro Antibacterial and Antibiotic Resistance Modifying Effect of Bioactive Plant Extracts on Methicillin-Resistant Staphylococcus epidermidis.

作者信息

Chovanová Romana, Mikulášová Mária, Vaverková Stefánia

机构信息

Department of Molecular Biology, Faculty of Natural Sciences, Comenius University, Mlynská Dolina, 842 15 Bratislava, Slovakia.

出版信息

Int J Microbiol. 2013;2013:760969. doi: 10.1155/2013/760969. Epub 2013 Oct 10.

DOI:10.1155/2013/760969
PMID:24222768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3810435/
Abstract

The crude extracts of plants from Asteraceae and Lamiaceae family and essential oils from Salvia officinalis and Salvia sclarea were studied for their antibacterial as well as antibiotic resistance modifying activity. Using disc diffusion and broth microdilution assays we determined higher antibacterial effect of three Salvia spp. and by evaluating the leakage of 260 nm absorbing material we detected effect of extracts and, namely, of essential oils on the disruption of cytoplasmic membrane. The evaluation of in vitro interactions between plant extracts and oxacillin described in terms of fractional inhibitory concentration (FIC) indices revealed synergistic or additive effects of plant extracts and clearly synergistic effects of essential oil from Salvia officinalis with oxacillin in methicillin-resistant Staphylococcus epidermidis.

摘要

对菊科和唇形科植物的粗提物以及鼠尾草和南欧丹参的精油进行了抗菌和抗生素抗性修饰活性研究。通过纸片扩散法和肉汤微量稀释法，我们测定了三种鼠尾草属植物具有更高的抗菌效果，并且通过评估260nm吸收物质的泄漏，我们检测到提取物尤其是精油对细胞质膜破坏的作用。以分数抑制浓度（FIC）指数描述的植物提取物与苯唑西林之间体外相互作用的评估显示，植物提取物具有协同或相加作用，并且在耐甲氧西林表皮葡萄球菌中，鼠尾草精油与苯唑西林具有明显的协同作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/715b/3810435/a9db0aa3dfca/IJMB2013-760969.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/715b/3810435/bae94bb3accf/IJMB2013-760969.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/715b/3810435/4221281e53cf/IJMB2013-760969.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/715b/3810435/23be9d8d6338/IJMB2013-760969.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/715b/3810435/a9db0aa3dfca/IJMB2013-760969.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/715b/3810435/bae94bb3accf/IJMB2013-760969.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/715b/3810435/4221281e53cf/IJMB2013-760969.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/715b/3810435/23be9d8d6338/IJMB2013-760969.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/715b/3810435/a9db0aa3dfca/IJMB2013-760969.004.jpg

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