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针对耐甲氧西林金黄色葡萄球菌的抗菌机制

Antibacterial Mechanism of Against Methicillin Resistant .

作者信息

Liu Xin, An Lili, Zhou Yonghui, Peng Wei, Huang Cong

机构信息

College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang City, People's Republic of China.

Dermatology Department, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, People's Republic of China.

出版信息

Infect Drug Resist. 2023 Mar 10;16:1345-1355. doi: 10.2147/IDR.S398227. eCollection 2023.

DOI:10.2147/IDR.S398227
PMID:36925724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10013587/
Abstract

PURPOSE

has become one of the most common causes of septicemia. Meanwhile, has acquired resistance to many antibiotics. Among these, methicillin-resistant (MRSE) were frequently isolated. Similar to methicillin resistant (MRSA), they also exhibited multi-resistance, which presented a danger to human health. as traditional Chinese medicine had strong antibacterial activity against MRSE. However, the mechanism of against MRSE is not clear.

METHODS

Here, the morphology of cell wall and cell membrane, production of β-lactamase and PBP2, energy metabolism, antioxidant system were systematically studied.

RESULTS

The data showed that damaged the cell wall and membrane. In addition, β-lactamase, energy metabolism and antioxidant system were involved in mechanisms of against MRSE.

CONCLUSION

These observations provided new understanding of against MRSE to control MRSE infections.

摘要

目的

已成为败血症最常见的病因之一。同时，已对多种抗生素产生耐药性。其中，耐甲氧西林的（MRSE）经常被分离出来。与耐甲氧西林的（MRSA）类似，它们也表现出多重耐药性，对人类健康构成威胁。作为传统中药，对MRSE具有较强的抗菌活性。然而，其抗MRSE的机制尚不清楚。

方法

在此，系统研究了细胞壁和细胞膜的形态、β-内酰胺酶和PBP2的产生、能量代谢、抗氧化系统。

结果

数据表明，破坏了细胞壁和细胞膜。此外，β-内酰胺酶、能量代谢和抗氧化系统参与了抗MRSE的机制。

结论

这些观察结果为抗MRSE以控制MRSE感染提供了新的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/5dd6612e9e8c/IDR-16-1345-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/cb9e0b83c69c/IDR-16-1345-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/42cd3fd980e6/IDR-16-1345-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/34063ade2553/IDR-16-1345-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/b49f9892037f/IDR-16-1345-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/effd507cece0/IDR-16-1345-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/d473e7a7c8a0/IDR-16-1345-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/5dd6612e9e8c/IDR-16-1345-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/cb9e0b83c69c/IDR-16-1345-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/42cd3fd980e6/IDR-16-1345-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/34063ade2553/IDR-16-1345-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/b49f9892037f/IDR-16-1345-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/effd507cece0/IDR-16-1345-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/d473e7a7c8a0/IDR-16-1345-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16d9/10013587/5dd6612e9e8c/IDR-16-1345-g0007.jpg

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