初乳抗体介导和细胞介导的免疫有助于仔猪的先天和抗原特异性免疫。
Colostral antibody-mediated and cell-mediated immunity contributes to innate and antigen-specific immunity in piglets.
机构信息
Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, United States.
Animal Science, College of Veterinary Medicine, Southern Research and Outreach Center, University of Minnesota, Waseca, MN 56093, United States.
出版信息
Dev Comp Immunol. 2014 Mar;43(1):114-20. doi: 10.1016/j.dci.2013.11.005. Epub 2013 Nov 16.
Immunoglobulins and immune cells are critical components of colostral immunity; however, their transfer to and function in the neonate, especially maternal lymphocytes, is unclear. Cell-mediated and antibody-mediated immunity in sow blood and colostrum and piglet blood before (PS) and after (AS) suckling were assessed to investigate transfer and function of maternal immunity in the piglet. CD4, CD8, and γδ lymphocytes were found in sow blood and colostrum and piglet blood PS and AS; each had a unique T lymphocyte profile. Immunoglobulins were detected in sow blood, colostrum, and in piglet blood AS; the immunoglobulin profile of piglet serum AS mimicked that of sow serum. These results suggest selectivity in lymphocyte concentration into colostrum and subsequent lymphocyte transfer into the neonate, but that immunoglobulin transfer is unimpeded. Assessment of colostral natural killer activity and antigen-specific proliferation revealed that colostral cells are capable of influencing the innate and specific immune response of neonatal pigs.
免疫球蛋白和免疫细胞是初乳免疫的关键组成部分；然而，它们在新生儿中的转移和功能，特别是母淋巴细胞的转移和功能，尚不清楚。本研究评估了母猪血液和初乳以及仔猪吸吮前后（PS 和 AS）的细胞介导和抗体介导免疫，以研究母源免疫在仔猪中的转移和功能。在母猪血液和初乳以及仔猪 PS 和 AS 血液中均发现了 CD4、CD8 和 γδ 淋巴细胞；每个都有独特的 T 淋巴细胞谱。在母猪血液、初乳和仔猪 AS 血液中均检测到免疫球蛋白；仔猪血清 AS 的免疫球蛋白谱与母猪血清相似。这些结果表明，淋巴细胞在初乳中的浓缩具有选择性，随后淋巴细胞转移到新生儿中，但免疫球蛋白的转移不受阻碍。对初乳自然杀伤活性和抗原特异性增殖的评估表明，初乳细胞能够影响新生仔猪的固有和特异性免疫反应。
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