Khan Usman Ali, Rahman Hazir, Niaz Zeeshan, Qasim Muhammad, Khan Jafar, Rehman Bushra
Eur J Microbiol Immunol (Bp). 2013 Dec;3(4):272-4. doi: 10.1556/EuJMI.3.2013.4.6. Epub 2013 Nov 21.
Medicinal plants are traditionally used for the treatment of human infections. The present study was undertaken to investigate Bergenia ciliata, Jasminum officinale, and Santalum album for their potential activity against human bacterial pathogens. B. ciliata, J. officinale, and S. album extracts were prepared in cold and hot water. The activity of plant extracts and selected antibiotics was evaluated against five bacterial pathogens including Staphylococcus aureus, Bacillus subtilis, Proteus vulgaris, Pseudomonas aeruginosa, and Escherichia coli using agar well diffusion method. Among the three medicinal plants, B. ciliata extracts displayed potential activity against bacterial pathogens. Cold water extract of Bergenia ciliate showed the highest activity against B. subtilis, which is comparable with a zone of inhibition exhibited by ceftriaxone and erythromycin. J. officinale and S. album extracts demonstrated variable antibacterial activity. Further studies are needed to explore the novel antibacterial bioactive molecules.
药用植物传统上用于治疗人类感染。本研究旨在调查岩白菜、素馨花和檀香对人类细菌病原体的潜在活性。岩白菜、素馨花和檀香提取物分别用冷水和热水制备。采用琼脂孔扩散法评估植物提取物和选定抗生素对包括金黄色葡萄球菌、枯草芽孢杆菌、普通变形杆菌、铜绿假单胞菌和大肠杆菌在内的五种细菌病原体的活性。在这三种药用植物中，岩白菜提取物对细菌病原体显示出潜在活性。岩白菜冷水提取物对枯草芽孢杆菌显示出最高活性，这与头孢曲松和红霉素的抑菌圈相当。素馨花和檀香提取物表现出不同的抗菌活性。需要进一步研究以探索新型抗菌生物活性分子。
