Depypere Herman T, Comhaire Frank H
Menopause Clinic, Department of Obstetrics and Gynecology, University Hospital of Ghent, De Pintelaan, 185, 9000 Gent, Belgium.
Emeritus, Department of Endocrinology and Metabolic Diseases, University Hospital of Ghent, De Pintelaan, 185, 9000 Gent, Belgium.
Maturitas. 2014 Feb;77(2):191-4. doi: 10.1016/j.maturitas.2013.11.001. Epub 2013 Nov 19.
Complementary and alternative medicines (CAM) such as isoflavones and black cohosh are commonly used to deal with menopausal symptoms, but benefit a limited proportion of women. The aim of this minireview is to summarize the evidence of the efficacy and safety of other herbal preparations. Randomized controlled trials (RCTs) find that the extracts of Mediterranean pine bark (Pycnogenol(®)), linseed, and Lepididium meyenii (Maca) reduce vasomotor symptoms. The results of RCTs of the hop flavonoid 8-prenylnaringenin are conflicting. Animal and human studies suggest that Dioscorea villosa (Wild yam),and Broccoli may protect against osteoporosis and breast and gynecological cancers but further evidence is required. Linseed may protect against breast cancer but the results are conflicting.
异黄酮和黑升麻等补充和替代药物（CAM）常用于缓解更年期症状，但仅对有限比例的女性有益。本综述的目的是总结其他草药制剂疗效和安全性的证据。随机对照试验（RCT）发现，地中海松树皮提取物（碧萝芷（®））、亚麻籽和玛卡可减轻血管舒缩症状。啤酒花类黄酮8-异戊烯基柚皮素的随机对照试验结果相互矛盾。动物和人体研究表明，薯蓣（野山药）和西兰花可能预防骨质疏松症以及乳腺癌和妇科癌症，但还需要更多证据。亚麻籽可能预防乳腺癌，但其结果相互矛盾。
