东亚地区患特应性皮炎犬皮肤分离出的厚皮马拉色菌对酮康唑和伊曲康唑的体外敏感性
In vitro susceptibility of Malassezia pachydermatis isolates from canine skin with atopic dermatitis to ketoconazole and itraconazole in East Asia.
作者信息
Watanabe Shion, Koike Anna, Kano Rui, Nagata Masahiko, Chen Charles, Hwang Cheol-Yong, Hasegawa Atsuhiko, Kamata Hiroshi
机构信息
Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan.
出版信息
J Vet Med Sci. 2014 Apr;76(4):579-81. doi: 10.1292/jvms.13-0433. Epub 2013 Dec 13.
Abstract
Topical or oral azole antifungals are commonly used in canine atopic dermatitis (AD), as the lipophilic yeast Malassezia pachydermatis exacerbates canine AD. To examine whether canine AD lesions harbor azole-resistant M. pachydermatis isolates in East Asia, we investigated the in vitro susceptibility of M. pachydermatis isolates to ketoconazole (KTZ) and itraconazole (ITZ) obtained from AD lesions of canines in Japan, Korea and Taiwan. The minimum inhibitory concentrations (MICs) of KTZ and ITZ were measured by the E-test using Sabouraud dextrose agar with 0.5% Tween 40. The MICs of KTZ and ITZ for isolates from canines with AD were significantly higher than the MICs for isolates from healthy canines. Our findings suggested that the clinical isolates from canine AD skin lesions were less susceptible to azoles than those from normal canine skin in East Asia.
摘要
局部或口服唑类抗真菌药常用于犬特应性皮炎（AD），因为亲脂性酵母厚皮马拉色菌会加重犬AD。为了研究东亚地区犬AD病变中是否存在对唑类耐药的厚皮马拉色菌分离株，我们调查了从日本、韩国和台湾犬的AD病变中获得的厚皮马拉色菌分离株对酮康唑（KTZ）和伊曲康唑（ITZ）的体外敏感性。使用含有0.5%吐温40的沙氏葡萄糖琼脂通过E试验测量KTZ和ITZ的最低抑菌浓度（MIC）。AD犬分离株的KTZ和ITZ的MIC显著高于健康犬分离株的MIC。我们的研究结果表明，东亚地区犬AD皮肤病变的临床分离株比正常犬皮肤的分离株对唑类的敏感性更低。
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