McEntee M, Isaacs W, Smith C
Department of Pathology, College of Veterinary Medicine, Cornell University.
Prostate. 1987;11(2):163-70. doi: 10.1002/pros.2990110207.
Thirty-one canine adenocarcinomas of prostatic origin were examined immunohistochemically with antibodies generated against three prostate-specific antigens by using a peroxidase-antiperoxidase technique. Primary antibodies included two generated with human prostatic antigens (PSA, PSAP) and one generated with a canine prostatic antigen (CPSP). Eight of 31 adenocarcinomas were positive with CPSP, two were positive with PSA, and three were PSAP positive. Normal and hyperplastic canine prostatic epithelium was strongly positive with all three markers. These results contrast with those in human studies in which PSA and PSAP stain normal and neoplastic epithelium with comparable intensity in all but the most anaplastic tumors.
采用过氧化物酶-抗过氧化物酶技术，用针对三种前列腺特异性抗原产生的抗体对31例前列腺源性犬腺癌进行免疫组织化学检查。一抗包括两种用人前列腺抗原产生的抗体（PSA、PSAP）和一种用犬前列腺抗原产生的抗体（CPSP）。31例腺癌中有8例CPSP呈阳性，2例PSA呈阳性，3例PSAP呈阳性。正常和增生的犬前列腺上皮对所有三种标志物均呈强阳性。这些结果与人类研究结果形成对比，在人类研究中，除了最间变的肿瘤外，PSA和PSAP对正常和肿瘤上皮的染色强度相当。
