Kim T, Kanayama Y, Negoro N, Okamura M, Takeda T, Inoue T
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Clin Exp Immunol. 1987 Dec;70(3):562-9.
Serum levels of alpha (alpha) and gamma (gamma)-interferons (IFN) were measured in 30 patients with untreated systemic lupus erythematosus (SLE) with a solid-phase, sandwich immunoradiometric assay using specific monoclonal antibodies. The serum levels of alpha-IFN were higher in patients with SLE than in normal subjects, and correlated with the clinical activity index (rs = 0.60, P less than 0.01), but not with renal histological activity. The serum level of alpha-IFN correlated with the serum level of immune complexes (r = 0.46, P less than 0.01) and the number of peripheral lymphocytes inversely (r = -0.49, P less than 0.01). Serum gamma-IFN levels were also higher in patients with SLE than in control subjects but no correlations were found between it and either clinical activity, renal histological activity or various laboratory parameters. Serum levels of both alpha-IFN and gamma-IFN were higher in SLE patients with erythema than in those without. These results suggested that serum levels of alpha-IFN were more closely related to clinical activity of SLE than were those of gamma-IFN, and that peripheral lymphocytes were probably not the source of the elevated serum IFN-alpha concentration.
采用固相夹心免疫放射分析法，使用特异性单克隆抗体，对30例未经治疗的系统性红斑狼疮（SLE）患者的血清α（α）和γ（γ）干扰素（IFN）水平进行了检测。SLE患者的血清α-IFN水平高于正常受试者，且与临床活动指数相关（rs = 0.60，P<0.01），但与肾脏组织学活动无关。血清α-IFN水平与免疫复合物水平相关（r = 0.46，P<0.01），与外周淋巴细胞数量呈负相关（r = -0.49，P<0.01）。SLE患者的血清γ-IFN水平也高于对照组，但未发现其与临床活动、肾脏组织学活动或各种实验室参数之间存在相关性。有红斑的SLE患者的血清α-IFN和γ-IFN水平均高于无红斑的患者。这些结果表明，血清α-IFN水平比γ-IFN水平与SLE的临床活动更密切相关，且外周淋巴细胞可能不是血清IFN-α浓度升高的来源。
