University of Urbino, Department of Biomolecular Sciences , Via Saffi, 2, 61029 Urbino , Italy +39 0722 305211 ;
Expert Opin Drug Deliv. 2014 May;11(5):677-87. doi: 10.1517/17425247.2014.889679. Epub 2014 Feb 19.
Drug delivery by means of erythrocytes is becoming a growing field with applications that in recent years have moved from the laboratory to the clinic. Several reviews have been published in recent years and have well illustrated the developments and the different fields of application. In this paper we have summarized the techniques that make the bases for these developments and provided illustrative examples on how the erythrocytes can be used in drug delivery.
We have illustrated the possibility of using erythrocytes for the slow delivery in circulation of active pharmaceutical ingredients (APIs), for the encapsulation of those ingredients that must remain confined within the erythrocyte, the encapsulation of drug-binding proteins (or protein domain) able to reversibly bind drugs of interest and for coupling of APIs on the surface of carrier erythrocytes.
Since many years erythrocytes are recognized as powerful cellular carriers for drugs. In this review, we briefly summarize different approaches that can be used to take advantage of these natural carriers. It is shown that several different APIs can be delivered by way of erythrocytes but the selection of the technique to be employed is crucial for a successful development. The examples illustrated can guide in selecting the most appropriate way of using erythrocytes as delivery systems.
通过红细胞进行药物输送正成为一个不断发展的领域，其应用近年来已从实验室转移到临床。近年来已经发表了几篇综述，很好地说明了这些发展和不同的应用领域。在本文中，我们总结了这些发展的基础技术，并提供了红细胞在药物输送中的应用示例。
我们说明了使用红细胞在循环中缓慢输送活性药物成分（APIs）、封装必须保持在红细胞内的成分、封装能够可逆结合感兴趣药物的药物结合蛋白（或蛋白结构域）以及将 API 偶联到载体红细胞表面的可能性。
多年来，红细胞已被公认为药物的强大细胞载体。在这篇综述中，我们简要总结了可以利用这些天然载体的不同方法。结果表明，几种不同的 API 可以通过红细胞输送，但选择要使用的技术对于成功开发至关重要。所说明的示例可以指导选择最适合将红细胞用作输送系统的方法。
