龟分枝杆菌和脓肿分枝杆菌菌株中诱导型大环内酯耐药性的快速分子检测：能否替代14天药敏试验？
Rapid molecular detection of inducible macrolide resistance in Mycobacterium chelonae and M. abscessus strains: a replacement for 14-day susceptibility testing?
作者信息
Hanson Kimberly E, Slechta E Susan, Muir Haleina, Barker Adam P
机构信息
Department of Medicine, University of Utah, Salt Lake City, Utah, USA.
出版信息
J Clin Microbiol. 2014 May;52(5):1705-7. doi: 10.1128/JCM.03464-13. Epub 2014 Feb 19.
Abstract
The erm(41) gene causes inducible macrolide resistance in Mycobacterium abscessus but not Mycobacterium chelonae. erm(41) sequencing of 285 M. abscessus and 45 M. chelonae isolates was compared to 14-day susceptibility; agreement percentages were 98.9% and 100%, respectively. Extended incubation may not be necessary for M. chelonae, and the erm(41) genotype is a useful adjunct for M. abscessus.
摘要
erm(41)基因可导致脓肿分枝杆菌对大环内酯类药物产生诱导性耐药，但对龟分枝杆菌无此作用。对285株脓肿分枝杆菌和45株龟分枝杆菌分离株进行erm(41)基因测序，并与14天药敏结果进行比较；符合率分别为98.9%和100%。对于龟分枝杆菌可能无需延长培养时间，而erm(41)基因型对脓肿分枝杆菌是一种有用的辅助手段。
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