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Rapid molecular detection of inducible macrolide resistance in Mycobacterium chelonae and M. abscessus strains: a replacement for 14-day susceptibility testing?龟分枝杆菌和脓肿分枝杆菌菌株中诱导型大环内酯耐药性的快速分子检测：能否替代14天药敏试验？
J Clin Microbiol. 2014 May;52(5):1705-7. doi: 10.1128/JCM.03464-13. Epub 2014 Feb 19.
2
A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae.一种新基因erm(41)可使脓肿分枝杆菌临床分离株产生诱导型大环内酯耐药性，但在龟分枝杆菌中不存在。
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Erm(41)-dependent inducible resistance to azithromycin and clarithromycin in clinical isolates of Mycobacterium abscessus.分支杆菌属脓肿临床分离株中 erm(41)依赖性诱导性耐阿奇霉素和克拉霉素。
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Comparison of drug-susceptibility patterns and gene sequences associated with clarithromycin and azithromycin resistance in complex isolates and evaluation of the accumulation of intrinsic macrolide resistance.复杂分离株中克拉霉素和阿奇霉素耐药相关的药物敏感性模式和基因序列比较，以及固有大环内酯类耐药的累积评估。
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本文引用的文献

1
Matrix-assisted laser desorption ionization-time of flight mass spectrometry can accurately differentiate between Mycobacterium masilliense (M. abscessus subspecies bolletti) and M. abscessus (sensu stricto).基质辅助激光解吸电离飞行时间质谱可准确区分马萨利分枝杆菌（脓肿分枝杆菌亚种博莱氏菌）和脓肿分枝杆菌（严格意义上的）。
J Clin Microbiol. 2013 Sep;51(9):3113-6. doi: 10.1128/JCM.01239-13. Epub 2013 Jul 3.
2
New rapid scheme for distinguishing the subspecies of the Mycobacterium abscessus group and identifying Mycobacterium massiliense isolates with inducible clarithromycin resistance.一种快速区分脓肿分枝杆菌群亚种和鉴定具有诱导克拉霉素耐药性的马萨利昂分枝杆菌分离株的新方案。
J Clin Microbiol. 2013 Sep;51(9):2943-9. doi: 10.1128/JCM.01132-13. Epub 2013 Jun 26.
3
Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study.全基因组测序鉴定囊性纤维化患者分枝杆菌脓肿之间的传播：一项回顾性队列研究。
Lancet. 2013 May 4;381(9877):1551-60. doi: 10.1016/S0140-6736(13)60632-7. Epub 2013 Mar 29.
4
MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.MEGA5：用于最大似然法、进化距离法和最大简约法的分子进化遗传学分析。
Mol Biol Evol. 2011 Oct;28(10):2731-9. doi: 10.1093/molbev/msr121. Epub 2011 May 4.
5
Assessment of clarithromycin susceptibility in strains belonging to the Mycobacterium abscessus group by erm(41) and rrl sequencing.通过 erm(41) 和 rrl 测序评估脓肿分枝杆菌属菌株对克拉霉素的敏感性。
Antimicrob Agents Chemother. 2011 Feb;55(2):775-81. doi: 10.1128/AAC.00861-10. Epub 2010 Dec 6.
6
Multilocus sequence analysis and rpoB sequencing of Mycobacterium abscessus (sensu lato) strains.多基因序列分析和 rpoB 测序鉴定脓肿分枝杆菌（狭义）菌株。
J Clin Microbiol. 2011 Feb;49(2):491-9. doi: 10.1128/JCM.01274-10. Epub 2010 Nov 24.
7
Clinical significance of differentiation of Mycobacterium massiliense from Mycobacterium abscessus.从脓肿分枝杆菌中区分马赛分枝杆菌的临床意义。
Am J Respir Crit Care Med. 2011 Feb 1;183(3):405-10. doi: 10.1164/rccm.201003-0395OC. Epub 2010 Sep 10.
8
Mycobacterium massiliense is differentiated from Mycobacterium abscessus and Mycobacterium bolletii by erythromycin ribosome methyltransferase gene (erm) and clarithromycin susceptibility patterns.马赛分枝杆菌可通过红霉素核糖体甲基化酶基因 (erm) 和克拉霉素药敏模式与脓肿分枝杆菌和博莱氏分枝杆菌相区分。
Microbiol Immunol. 2010 Jun;54(6):347-53. doi: 10.1111/j.1348-0421.2010.00221.x.
9
Inaccuracy of single-target sequencing for discriminating species of the Mycobacterium abscessus group.单靶点测序在区分脓肿分枝杆菌组菌种方面的准确性欠佳。
J Clin Microbiol. 2009 Aug;47(8):2596-600. doi: 10.1128/JCM.00037-09. Epub 2009 Jun 10.
10
Cohort study of molecular identification and typing of Mycobacterium abscessus, Mycobacterium massiliense, and Mycobacterium bolletii.脓肿分枝杆菌、马赛分枝杆菌和博勒分枝杆菌分子鉴定与分型的队列研究
J Clin Microbiol. 2009 Jul;47(7):1985-95. doi: 10.1128/JCM.01688-08. Epub 2009 May 6.

龟分枝杆菌和脓肿分枝杆菌菌株中诱导型大环内酯耐药性的快速分子检测：能否替代14天药敏试验？

Rapid molecular detection of inducible macrolide resistance in Mycobacterium chelonae and M. abscessus strains: a replacement for 14-day susceptibility testing?

作者信息

Hanson Kimberly E, Slechta E Susan, Muir Haleina, Barker Adam P

机构信息

Department of Medicine, University of Utah, Salt Lake City, Utah, USA.

出版信息

J Clin Microbiol. 2014 May;52(5):1705-7. doi: 10.1128/JCM.03464-13. Epub 2014 Feb 19.

DOI:10.1128/JCM.03464-13
PMID:24554745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3993676/
Abstract

The erm(41) gene causes inducible macrolide resistance in Mycobacterium abscessus but not Mycobacterium chelonae. erm(41) sequencing of 285 M. abscessus and 45 M. chelonae isolates was compared to 14-day susceptibility; agreement percentages were 98.9% and 100%, respectively. Extended incubation may not be necessary for M. chelonae, and the erm(41) genotype is a useful adjunct for M. abscessus.

摘要

erm(41)基因可导致脓肿分枝杆菌对大环内酯类药物产生诱导性耐药，但对龟分枝杆菌无此作用。对285株脓肿分枝杆菌和45株龟分枝杆菌分离株进行erm(41)基因测序，并与14天药敏结果进行比较；符合率分别为98.9%和100%。对于龟分枝杆菌可能无需延长培养时间，而erm(41)基因型对脓肿分枝杆菌是一种有用的辅助手段。