利福布汀与1型人类免疫缺陷病毒之间的相互作用：体外对病毒复制、细胞病变效应及逆转录酶的抑制作用
Interaction between rifabutin and human immunodeficiency virus type 1: inhibition of replication, cytopathic effect, and reverse transcriptase in vitro.
作者信息
Anand R, Moore J L, Curran J W, Srinivasan A
机构信息
AIDS Program, Centers for Disease Control, Atlanta, Georgia 30333.
出版信息
Antimicrob Agents Chemother. 1988 May;32(5):684-8. doi: 10.1128/AAC.32.5.684.
Abstract
Rifabutin (ansamycin; LM427), a semisynthetic rifamycin derivative, inhibits the replication of human immunodeficiency virus type 1, the virus etiologically linked to acquired immunodeficiency syndrome. The inhibition of virus production was observed in human immunodeficiency virus type 1-infected peripheral blood mononuclear cells both by reverse transcriptase assay and virus-antigen assay. In addition, rifabutin effectively reduced human immunodeficiency virus type 1-associated cytopathic effect to OKT4-positive cells. Virion-associated reverse transcriptase was also markedly inhibited by rifabutin. The inhibitory dose of rifabutin was nontoxic to lymphoid cells, which further suggests that it might serve as a useful agent in the therapeutic modalities of acquired immunodeficiency syndrome.
摘要
利福布汀（安莎霉素；LM427），一种半合成利福霉素衍生物，可抑制1型人类免疫缺陷病毒的复制，该病毒在病因上与获得性免疫缺陷综合征相关。通过逆转录酶测定和病毒抗原测定，在1型人类免疫缺陷病毒感染的外周血单核细胞中观察到病毒产生受到抑制。此外，利福布汀有效地降低了1型人类免疫缺陷病毒对OKT4阳性细胞的细胞病变效应。利福布汀对病毒体相关的逆转录酶也有明显抑制作用。利福布汀的抑制剂量对淋巴细胞无毒，这进一步表明它可能是获得性免疫缺陷综合征治疗模式中的一种有用药物。
相似文献
1
Interaction between rifabutin and human immunodeficiency virus type 1: inhibition of replication, cytopathic effect, and reverse transcriptase in vitro.利福布汀与1型人类免疫缺陷病毒之间的相互作用：体外对病毒复制、细胞病变效应及逆转录酶的抑制作用
Antimicrob Agents Chemother. 1988 May;32(5):684-8. doi: 10.1128/AAC.32.5.684.
2
Inhibition of replication and cytopathic effect of human T cell lymphotropic virus type III/lymphadenopathy-associated virus by 3'-azido-3'-deoxythymidine in vitro.3'-叠氮-3'-脱氧胸苷在体外对人嗜T细胞病毒III型/淋巴结病相关病毒复制及细胞病变效应的抑制作用
Antimicrob Agents Chemother. 1986 Dec;30(6):933-7. doi: 10.1128/AAC.30.6.933.
3
Suramin in the treatment of AIDS: mechanism of action.
Antiviral Res. 1987 Jan;7(1):1-10. doi: 10.1016/0166-3542(87)90034-9.
4
[Inhibition of human immunodeficiency virus replication by azidothymidine (Azitidín Lachema) in cultured cells].
Bratisl Lek Listy. 1993 Feb;94(2):76-80.
5
Diarylsulfones, a new chemical class of nonnucleoside antiviral inhibitors of human immunodeficiency virus type 1 reverse transcriptase.二芳基砜类化合物，一类新型的人免疫缺陷病毒1型逆转录酶非核苷类抗病毒抑制剂。
Antimicrob Agents Chemother. 1993 Apr;37(4):754-60. doi: 10.1128/AAC.37.4.754.
6
Resumption of virus production after human immunodeficiency virus infection of T lymphocytes in the presence of azidothymidine.在叠氮胸苷存在的情况下，人类免疫缺陷病毒感染T淋巴细胞后病毒产生的恢复。
J Virol. 1987 Dec;61(12):3769-73. doi: 10.1128/JVI.61.12.3769-3773.1987.
7
Derivatives of 4-amino-3,6-disulfonato-1,8-naphthalimide inhibit reverse transcriptase and suppress human and feline immunodeficiency virus expression in cultured cells.4-氨基-3,6-二磺酸基-1,8-萘二甲酰亚胺的衍生物可抑制逆转录酶，并抑制培养细胞中的人类和猫免疫缺陷病毒表达。
J Cell Biochem. 1993 Apr;51(4):446-57. doi: 10.1002/jcb.2400510410.
8
Effect of retinoic acid on the replication of human immunodeficiency virus in HTLV-I-positive MT-4 cells.维甲酸对人免疫缺陷病毒在人T淋巴细胞白血病病毒I型阳性MT - 4细胞中复制的影响。
Med Microbiol Immunol. 1987;176(4):189-98. doi: 10.1007/BF00196686.
9
Rifabutin (ansamycin LM 427): a new rifamycin-S derivative for the treatment of mycobacterial diseases.利福布汀（安莎霉素LM 427）：一种用于治疗分枝杆菌病的新型利福霉素-S衍生物。
Rev Infect Dis. 1987 May-Jun;9(3):519-30. doi: 10.1093/clinids/9.3.519.
引用本文的文献
1
Mycobacterial infection in patients infected with the human immunodeficiency virus.感染人类免疫缺陷病毒患者的分枝杆菌感染
Thorax. 1990 Jan;45(1):45-8. doi: 10.1136/thx.45.1.45.
2
Illimaquinone, a selective inhibitor of the RNase H activity of human immunodeficiency virus type 1 reverse transcriptase.伊利马醌，一种人类免疫缺陷病毒1型逆转录酶核糖核酸酶H活性的选择性抑制剂。
Antimicrob Agents Chemother. 1990 Oct;34(10):2009-12. doi: 10.1128/AAC.34.10.2009.
3
Mycobacterial diseases of the gut: some impact from molecular biology.肠道分枝杆菌病：分子生物学的一些影响
Gut. 1992 Feb;33(2):145-7. doi: 10.1136/gut.33.2.145.
本文引用的文献
1
Viral protein expression in producer and nonproducer clones of friend erythroleukemia cell lines.Friend红白血病细胞系的产生克隆和非产生克隆中的病毒蛋白表达。
J Virol. 1981 Feb;37(2):654-60. doi: 10.1128/JVI.37.2.654-660.1981.
2
Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes.淋巴结病相关病毒（LAV）对辅助诱导性T淋巴细胞的选择性嗜性。
Science. 1984 Jul 6;225(4657):59-63. doi: 10.1126/science.6328660.
3
LM 427, a new spiropiperidylrifamycin: in vitro and in vivo studies.LM 427，一种新型螺哌啶基利福霉素：体外和体内研究
J Antibiot (Tokyo). 1983 Nov;36(11):1502-6. doi: 10.7164/antibiotics.36.1502.
4
In vitro susceptibility of Mycobacterium avium complex and Mycobacterium tuberculosis strains to a spiro-piperidyl rifamycin.鸟分枝杆菌复合群及结核分枝杆菌菌株对一种螺哌啶基利福霉素的体外敏感性
Am Rev Respir Dis. 1982 Sep;126(3):586-7. doi: 10.1164/arrd.1982.126.3.586.
5
Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS.从旧金山艾滋病患者中分离淋巴细胞病变逆转录病毒。
Science. 1984 Aug 24;225(4664):840-2. doi: 10.1126/science.6206563.
6
Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.从艾滋病患者和有患艾滋病风险的人群中频繁检测和分离出细胞病变逆转录病毒（HTLV-III）。
Science. 1984 May 4;224(4648):500-3. doi: 10.1126/science.6200936.
7
Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS.从艾滋病患者和艾滋病前期患者中检测、分离并持续生产细胞病变逆转录病毒（HTLV-III）。
Science. 1984 May 4;224(4648):497-500. doi: 10.1126/science.6200935.
8
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).从一名有获得性免疫缺陷综合征（艾滋病）风险的患者体内分离出一种嗜T淋巴细胞逆转录病毒。
Science. 1983 May 20;220(4599):868-71. doi: 10.1126/science.6189183.
9
Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III.苏拉明在体外对T细胞的保护作用，使其免受人类嗜T淋巴细胞病毒III型（HTLV-III）的感染性和细胞病变效应的影响。
Science. 1984 Oct 12;226(4671):172-4. doi: 10.1126/science.6091268.
10
Interaction between murine type-C virus RNA-directed DNA polymerases and rifamycin derivatives.鼠类C型病毒RNA指导的DNA聚合酶与利福霉素衍生物之间的相互作用。
Biochim Biophys Acta. 1974 Apr 10;340(4):419-36. doi: 10.1016/0005-2787(74)90063-x.
Zotero 插件