对活体视网膜中的单细胞进行成像。
Imaging single cells in the living retina.
作者信息
Williams David R
机构信息
Center for Visual Science, William G. Allyn Professor of Medical Optics, University of Rochester, Rochester, NY 14627-0270, United States.
出版信息
Vision Res. 2011 Jul 1;51(13):1379-96. doi: 10.1016/j.visres.2011.05.002. Epub 2011 May 10.
Abstract
A quarter century ago, we were limited to a macroscopic view of the retina inside the living eye. Since then, new imaging technologies, including confocal scanning laser ophthalmoscopy, optical coherence tomography, and adaptive optics fundus imaging, transformed the eye into a microscope in which individual cells can now be resolved noninvasively. These technologies have enabled a wide range of studies of the retina that were previously impossible.
摘要
四分之一个世纪以前，我们对活眼内视网膜的观察还局限于宏观层面。从那时起，包括共焦扫描激光检眼镜、光学相干断层扫描和自适应光学眼底成像在内的新型成像技术，将眼睛变成了一台显微镜，现在可以在不进行侵入性操作的情况下分辨出单个细胞。这些技术使得以前无法开展的一系列视网膜研究成为可能。
相似文献
1
Imaging single cells in the living retina.对活体视网膜中的单细胞进行成像。
Vision Res. 2011 Jul 1;51(13):1379-96. doi: 10.1016/j.visres.2011.05.002. Epub 2011 May 10.
2
Adaptive optics retinal imaging: emerging clinical applications.自适应光学视网膜成像：新兴的临床应用
Optom Vis Sci. 2010 Dec;87(12):930-41. doi: 10.1097/OPX.0b013e3181ff9a8b.
3
The fundus photo has met its match: optical coherence tomography and adaptive optics ophthalmoscopy are here to stay.眼底照片遇到了对手：光学相干断层扫描和自适应光学检眼镜将继续存在。
Ophthalmic Physiol Opt. 2016 May;36(3):218-39. doi: 10.1111/opo.12289.
4
Foveal cone count reduction in resolved endophthalmitis: an adaptive optics scanning laser ophthalmoscopy (AO-SLO)-based prospective pilot study. resolved 眼内炎中中央凹锥体细胞计数减少：基于自适应光学扫描激光检眼镜（AO-SLO）的前瞻性初步研究。
Br J Ophthalmol. 2021 Nov;105(11):1520-1524. doi: 10.1136/bjophthalmol-2020-317309. Epub 2020 Sep 11.
5
Adaptive optics ophthalmoscopy: results and applications.自适应光学检眼镜：结果与应用
J Refract Surg. 2005 Sep-Oct;21(5):S570-4. doi: 10.3928/1081-597X-20050901-29.
6
Retinal Vascular Diseases Highlighted by Adaptive Optics Ophthalmoscopy.自适应光学检眼镜凸显的视网膜血管疾病
Rom J Ophthalmol. 2025 Jan-Mar;69(1):36-41. doi: 10.22336/rjo.2025.07.
7
LONGITUDINAL ADAPTIVE OPTICS SCANNING LASER OPHTHALMOSCOPY REVEALS REGIONAL VARIATION IN CONE AND ROD PHOTORECEPTOR LOSS IN STARGARDT DISEASE.纵向自适应光学扫描激光检眼镜显示斯塔加特病中视锥和视杆光感受器的丢失存在区域性差异。
Retina. 2024 Aug 1;44(8):1403-1412. doi: 10.1097/IAE.0000000000004104.
8
Alterations to the Foveal Cone Mosaic of Diabetic Patients.糖尿病患者中央凹视锥细胞镶嵌的改变。
Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3395-3403. doi: 10.1167/iovs.17-21793.
9
Imaging the photoreceptor mosaic with adaptive optics: beyond counting cones.用自适应光学技术对光感受器嵌合体进行成像：超越锥体细胞计数。
Adv Exp Med Biol. 2012;723:451-8. doi: 10.1007/978-1-4614-0631-0_57.
10
CONE PHOTORECEPTOR INTEGRITY ASSESSED WITH ADAPTIVE OPTICS IMAGING AFTER LASER POINTER-INDUCED RETINAL INJURY.激光指针诱导的视网膜损伤后应用自适应光学成像评估视锥细胞完整性。
Retin Cases Brief Rep. 2022 Sep 1;16(5):586-592. doi: 10.1097/ICB.0000000000001025.
引用本文的文献
1
Axicons for improved resolution and depth of focus in adaptive optics scanning light ophthalmoscopy.用于自适应光学扫描激光检眼镜中提高分辨率和焦深的轴棱锥。
Biomed Opt Express. 2025 Jul 16;16(8):3172-3193. doi: 10.1364/BOE.564398. eCollection 2025 Aug 1.
2
Visible-light optical coherence tomography and its applications.可见光光学相干断层扫描及其应用。
Neurophotonics. 2025 Apr;12(2):020601. doi: 10.1117/1.NPh.12.2.020601. Epub 2025 Apr 9.
3
Characterizing Presumed Displaced Retinal Ganglion Cells in the Living Human Retina of Healthy and Glaucomatous Eyes.描述健康和青光眼眼中活体人视网膜中假定的移位神经节细胞。
Invest Ophthalmol Vis Sci. 2024 Sep 3;65(11):20. doi: 10.1167/iovs.65.11.20.
4
High-Resolution Imaging of Cones and Retinal Arteries in Patients with Diabetes Mellitus Type 1 Using Adaptive Optics (rtx1).使用自适应光学技术（rtx1）对1型糖尿病患者的视锥细胞和视网膜动脉进行高分辨率成像。
Biomedicines. 2024 Apr 14;12(4):863. doi: 10.3390/biomedicines12040863.
5
Stem cell sources and characterization in the development of cell-based products for treating retinal disease: An NEI Town Hall report.干细胞来源和鉴定在用于治疗视网膜疾病的基于细胞产品开发中的应用：NEI 研讨会报告。
Stem Cell Res Ther. 2023 Mar 29;14(1):53. doi: 10.1186/s13287-023-03282-y.
6
Ultrahigh-speed multimodal adaptive optics system for microscopic structural and functional imaging of the human retina.用于人类视网膜微观结构和功能成像的超高速多模态自适应光学系统。
Biomed Opt Express. 2022 Oct 17;13(11):5860-5878. doi: 10.1364/BOE.462594. eCollection 2022 Nov 1.
7
Adaptive Optics Imaging of Inherited Retinal Disease.遗传性视网膜疾病的自适应光学成像
Cold Spring Harb Perspect Med. 2023 Jul 5;13(7):a041285. doi: 10.1101/cshperspect.a041285.
8
Intergrader agreement of foveal cone topography measured using adaptive optics scanning light ophthalmoscopy.使用自适应光学扫描激光检眼镜测量的黄斑中心凹视锥细胞地形图的评分者间一致性。
Biomed Opt Express. 2022 Aug 1;13(8):4445-4454. doi: 10.1364/BOE.460821.
9
Evaluation of Morphological Changes in Retinal Vessels in Type 1 Diabetes Mellitus Patients with the Use of Adaptive Optics.利用自适应光学技术评估1型糖尿病患者视网膜血管的形态学变化
Biomedicines. 2022 Aug 9;10(8):1926. doi: 10.3390/biomedicines10081926.
10
Comparison of Cone Mosaic Metrics From Images Acquired With the SPECTRALIS High Magnification Module and Adaptive Optics Scanning Light Ophthalmoscopy.高倍模块光谱仪图像与自适应光学扫描检眼镜获取的锥细胞马赛克指标的比较。
Transl Vis Sci Technol. 2022 May 2;11(5):19. doi: 10.1167/tvst.11.5.19.
本文引用的文献
1
Noninvasive imaging of the human rod photoreceptor mosaic using a confocal adaptive optics scanning ophthalmoscope.使用共焦自适应光学扫描检眼镜对人类视杆光感受器镶嵌进行无创成像。
Biomed Opt Express. 2011 Jul 1;2(7):1864-76. doi: 10.1364/BOE.2.001864. Epub 2011 Jun 8.
2
Reflective afocal broadband adaptive optics scanning ophthalmoscope.反射式无焦宽带自适应光学扫描检眼镜。
Biomed Opt Express. 2011 Jun 1;2(6):1757-68. doi: 10.1364/BOE.2.001757. Epub 2011 May 27.
3
Characterization of single-file flow through human retinal parafoveal capillaries using an adaptive optics scanning laser ophthalmoscope.使用自适应光学扫描激光检眼镜对人视网膜旁中央凹毛细血管中单分子流的表征。
Biomed Opt Express. 2011 Mar 2;2(4):781-93. doi: 10.1364/BOE.2.000781.
4
Imaging cone photoreceptors in three dimensions and in time using ultrahigh resolution optical coherence tomography with adaptive optics.使用具有自适应光学的超高分辨率光学相干断层扫描在三维空间和时间上对视锥光感受器进行成像。
Biomed Opt Express. 2011 Mar 1;2(4):748-63. doi: 10.1364/BOE.2.000748.
5
Optical properties of the mouse eye.小鼠眼睛的光学特性。
Biomed Opt Express. 2011 Feb 28;2(4):717-38. doi: 10.1364/BOE.2.000717.
6
Noninvasive measurements and analysis of blood velocity profiles in human retinal vessels.无创测量和分析人体视网膜血管中的血流速度剖面。
Invest Ophthalmol Vis Sci. 2011 Jun 13;52(7):4151-7. doi: 10.1167/iovs.10-6940.
7
Imaging light responses of targeted neuron populations in the rodent retina.在鼠类视网膜中对靶向神经元群体进行光响应成像。
J Neurosci. 2011 Feb 23;31(8):2855-67. doi: 10.1523/JNEUROSCI.6064-10.2011.
8
Adaptive optics and the eye (super resolution OCT).自适应光学与眼睛（超分辨率 OCT）。
Eye (Lond). 2011 Mar;25(3):321-30. doi: 10.1038/eye.2011.1.
9
Imaging retinal mosaics in the living eye.活体眼视网膜镶嵌成像。
Eye (Lond). 2011 Mar;25(3):301-8. doi: 10.1038/eye.2010.221.
10
Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy.利用自适应光学双光子眼科显微镜获取的活体灵长类动物眼睛中光感受器的图像。
Biomed Opt Express. 2010 Dec 17;2(1):139-48. doi: 10.1364/BOE.2.000139.
Zotero 插件