Department of Oral Pathology, St Joseph Dental College & Hospital, Duggirala, Eluru 534003, India ; Anuradha ENT Hospital, D/No-10/200, Eluru Road, Gudivada, Krishna District, Andhra Pradesh 521301, India.
Department of Oral Pathology, St Joseph Dental College & Hospital, Duggirala, Eluru 534003, India.
J Oncol. 2014;2014:614291. doi: 10.1155/2014/614291. Epub 2014 Jan 23.
Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology and a substantial role in tumor angiogenesis. Angiogenesis is a complex process that is tightly regulated by various growth factors in which mast cells act directly by releasing angiogenic factors and henceforth promoting tumor growth and metastasis. The aim of this study is to evaluate the number of mast cells in tissue sections of oral squamous cell carcinoma (OSCC) in comparison with normal mucosa. A total of 40 cases (20 OSCC and 20 normal mucosa) were stained with 1% toluidine blue and the quantitative analysis was done by using light microscope under 400x magnification. A significant increase in the mast cell count was observed in the sections of OSCC when compared to normal mucosa suggesting their contributing role in tumor growth and progression.
肥大细胞被认为是复杂且多功能的细胞，在免疫病理学中起着重要作用，在肿瘤血管生成中也起着重要作用。血管生成是一个复杂的过程，受各种生长因子的严格调控，其中肥大细胞通过直接释放血管生成因子来促进肿瘤生长和转移。本研究旨在评估口腔鳞状细胞癌（OSCC）组织切片中肥大细胞的数量，并与正常黏膜进行比较。共对 40 例标本（20 例 OSCC 和 20 例正常黏膜）进行了 1%甲苯胺蓝染色，并在 400x 放大倍数下使用光学显微镜进行了定量分析。与正常黏膜相比，OSCC 组织切片中肥大细胞计数显著增加，表明它们在肿瘤生长和进展中起作用。
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