Arpicco Silvia, Milla Paola, Stella Barbara, Dosio Franco
Dipartimento di Scienza e Tecnologia del Farmaco (Department of Drug Science and Technology), University of Torino, Torino, I-10125, Italy.
Molecules. 2014 Mar 17;19(3):3193-230. doi: 10.3390/molecules19033193.
Hyaluronic acid (HA) is a naturally-occurring glycosaminoglycan and a major component of the extracellular matrix. Low levels of the hyaluronic acid receptor CD44 are found on the surface of epithelial, hematopoietic, and neuronal cells; it is overexpressed in many cancer cells, and in particular in tumor-initiating cells. HA has recently attracted considerable interest in the field of developing drug delivery systems, having been used, as such or encapsulated in different types of nanoassembly, as ligand to prepare nano-platforms for actively targeting drugs, genes, and diagnostic agents. This review describes recent progress made with the several chemical strategies adopted to synthesize conjugates and prepare novel delivery systems with improved behaviors.
透明质酸（HA）是一种天然存在的糖胺聚糖，也是细胞外基质的主要成分。上皮细胞、造血细胞和神经细胞表面存在低水平的透明质酸受体CD44；它在许多癌细胞中过度表达，尤其是在肿瘤起始细胞中。透明质酸最近在药物递送系统的开发领域引起了相当大的关注，它本身或被封装在不同类型的纳米组装体中，作为配体用于制备用于主动靶向药物、基因和诊断剂的纳米平台。本文综述了采用几种化学策略合成共轭物并制备具有改进性能的新型递送系统所取得的最新进展。
