Department of Public Health, Hjelt Institute, University of Helsinki, Mannerheimintie 172, PL41, 00014, Helsinki, Finland,
Qual Life Res. 2014 Oct;23(8):2319-26. doi: 10.1007/s11136-014-0674-z. Epub 2014 Mar 28.
To examine and compare health-related quality of life (HRQoL) in people with previously known diabetes, new screen-detected asymptomatic diabetes and people without diabetes.
HRQoL of 4,613 individuals who participated in a population-based cross-sectional diabetes survey in Qingdao, China, in 2009, was assessed using the 15D instrument. A Tobit regression model to estimate the effects of diabetes on HRQoL separate from effects of other health determinants was constructed.
Among the surveyed population, 220 (4.8%) individuals had previously known diabetes and 531 (11.5%) individuals had new screen-detected diabetes, defined by fasting plasma glucose ≥7.0 mmol/l and/or 2-h plasma glucose ≥11.1 mmol/l. The age-, gender-, and BMI-adjusted mean 15D score of people without diabetes, with new screen-detected diabetes, and previously known diabetes was 0.975, 0.975, and 0.964, respectively, for urban and 0.971, 0.972, and 0.960, respectively, for rural participants. HRQoL overall and on all the dimensions (p < 0.05) except for hearing, eating, and speech was worse in the people with previously known diabetes compared to those with new screen-detected diabetes and those without diabetes. Compared to people without diabetes, people with new screen-detected diabetes were worse off on the dimension of usual activities (p < 0.05). After adjusting for comorbid diseases and other confounders, the impact of diabetes on reduced HRQoL was diminished.
Health-related quality of life was impaired in people with previously known diabetes who had co-morbid conditions, but was largely unaltered in people with newly detected asymptomatic diabetes as compared to people without diabetes.
检测和比较已知糖尿病、新筛查无症状糖尿病及无糖尿病患者的健康相关生活质量（HRQoL）。
2009 年，在中国青岛进行的一项基于人群的横断面糖尿病调查中，对 4613 名参与者的 HRQoL 使用 15D 工具进行评估。构建了一个 Tobit 回归模型，以单独估计糖尿病对 HRQoL 的影响，而不受其他健康决定因素的影响。
在所调查的人群中，220 名（4.8%）个体患有先前已知的糖尿病，531 名（11.5%）个体患有新筛查无症状糖尿病，定义为空腹血糖≥7.0mmol/l 和/或 2 小时血糖≥11.1mmol/l。调整年龄、性别和 BMI 后，无糖尿病、新筛查无症状糖尿病和先前已知糖尿病的城市参与者的平均 15D 评分分别为 0.975、0.975 和 0.964，农村参与者的平均 15D 评分分别为 0.971、0.972 和 0.960。总的来说，除了听力、饮食和言语之外，所有维度（p<0.05）的 HRQoL 在先前已知糖尿病患者中都较差，与新筛查无症状糖尿病患者和无糖尿病患者相比。与无糖尿病患者相比，新筛查无症状糖尿病患者在日常活动维度上的表现更差（p<0.05）。在调整了合并疾病和其他混杂因素后，糖尿病对降低 HRQoL 的影响减弱。
与无糖尿病患者相比，患有合并症的先前已知糖尿病患者的健康相关生活质量受损，但新筛查无症状糖尿病患者的健康相关生活质量基本未受影响。
