肽AS-48对粪肠球菌亚种液化亚种S-47的作用。
Effect of peptide AS-48 on Enterococcus faecalis subsp. liquefaciens S-47.
作者信息
Galvez A, Valdivia E, Martinez M, Maqueda M
机构信息
Departamento de Microbiologia, Facultad de Ciencias, Universidad de Granada, Spain.
出版信息
Antimicrob Agents Chemother. 1989 May;33(5):641-5. doi: 10.1128/AAC.33.5.641.
Abstract
The enterococcal peptide AS-48 exerts a concentration-dependent bactericidal effect on Enterococcus faecalis subsp. liquefaciens S-47; cell rescue by cardiolipin and trypsin can be effected only in the first few minutes after antibiotic addition. Gramicidin-exposed cells are protected from killing by AS-48. Long-term and pulse incorporation of radiolabeled substrates into trichloroacetic acid-precipitable material, O2 consumption, and the ability to maintain intracellular potassium levels are impaired shortly after addition of AS-48.
摘要
肠球菌肽AS-48对粪肠球菌亚种液化粪肠球菌S-47具有浓度依赖性杀菌作用；心磷脂和胰蛋白酶对细胞的挽救作用仅在添加抗生素后的最初几分钟内有效。暴露于短杆菌肽的细胞可免受AS-48的杀伤。添加AS-48后不久，放射性标记底物长期和脉冲掺入三氯乙酸沉淀物质、耗氧量以及维持细胞内钾水平的能力均受损。
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