Malleson P, Petty R E, Fung M, Candido E P
Department of Pediatrics, University of British Columbia, Vancouver, Canada.
Arthritis Rheum. 1989 Jul;32(7):919-23.
Antinuclear antibodies are found in serum samples from most children with juvenile rheumatoid arthritis (JRA), but the antigenic specificities of these antibodies are not known. Using an immunoblot technique, we found that JRA patients' sera react with a variety of proteins in the nuclei of HEp-2 cells. Antibody to histone H1 was found in 42% of the JRA serum samples. An IgG antibody to a 45-kd protein was found in serum samples from some patients without uveitis, but it was not found in any sample from patients with uveitis. The immunoblot reactivity patterns do not appear to be useful in distinguishing between disease onset types or disease course types in patients with JRA.
在大多数青少年类风湿性关节炎（JRA）患儿的血清样本中可检测到抗核抗体，但这些抗体的抗原特异性尚不清楚。运用免疫印迹技术，我们发现JRA患者的血清可与HEp-2细胞核中的多种蛋白质发生反应。在42%的JRA血清样本中发现了组蛋白H1抗体。在一些无葡萄膜炎患者的血清样本中发现了一种针对45-kd蛋白的IgG抗体，但在葡萄膜炎患者的任何样本中均未发现。免疫印迹反应模式似乎无助于区分JRA患者的疾病起病类型或病程类型。
