Hulimavu Shwetha R, Mohanty Leeky, Tondikulam Narayan V, Shenoy Sadhana, Jamadar Saleha, Bhadranna Abhishek
Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bengaluru, Karnataka, India.
J Oral Pathol Med. 2014 Sep;43(8):576-8. doi: 10.1111/jop.12194. Epub 2014 Apr 25.
Oral lichen planus is a T-cell-mediated mucosal disease of unknown etiology. Numerous predisposing factors have been put forward in the etiology of this disease. This includes stress, drugs, genetic susceptibility, certain viruses, and bacterial infections. Recently, there have been studies published on possible role of Helicobacter pylori infection in pathogenesis of mucocutaneous diseases including oral lichen planus (OLP). The aim of this study was to detect immunohistochemically the presence of Helicobacter pylori in oral lichen planus.
Paraffin-embedded tissue blocks of 50 cases of OLP and 10 cases of normal buccal mucosal biopsies and 6 endoscopic biopsies of patients with peptic ulcer (control group) were sectioned and stained by hematoxylin and eosin. Serial sections of same were stained immunohistochemically using Anti-Helicobacter pylori antibody and observed under microscope for presence or absence of Helicobacter pylori.
Except for the control group, none of the cases of OLP and normal buccal mucosal biopsies showed positivity for Helicobacter pylori.
As we did not detect the presence of Helicobacter pylori in any of the OLP cases, we question the role of these organisms in the pathogenesis of OLP planus if any.
口腔扁平苔藓是一种病因不明的T细胞介导的黏膜疾病。该疾病的病因中已提出了许多诱发因素。这包括压力、药物、遗传易感性、某些病毒和细菌感染。最近，有关于幽门螺杆菌感染在包括口腔扁平苔藓（OLP）在内的皮肤黏膜疾病发病机制中可能作用的研究发表。本研究的目的是通过免疫组织化学方法检测口腔扁平苔藓中幽门螺杆菌的存在情况。
将50例OLP患者的石蜡包埋组织块、10例正常颊黏膜活检组织块以及6例消化性溃疡患者的内镜活检组织（对照组）进行切片，并用苏木精和伊红染色。对相同的连续切片使用抗幽门螺杆菌抗体进行免疫组织化学染色，并在显微镜下观察幽门螺杆菌的有无。
除对照组外，OLP病例和正常颊黏膜活检组织均未显示幽门螺杆菌阳性。
由于我们在任何OLP病例中均未检测到幽门螺杆菌的存在，因此我们质疑这些微生物在OLP发病机制中是否起作用（若有作用的话）。
