Damodar G, Gopinath S, Vijayakumar S, Rao A Yedukondala
Department of Pharmacy Practice, Vaagdevi College of Pharmacy, Kakatiya University, Warangal-506 007, India.
Department of Oncology, MGM Hospital, Kakatiya Medical College, Warangal-506 007, India.
Indian J Pharm Sci. 2014 Jan;76(1):2-9.
Over the last decade, quality of life investigations of cancer patients' have became a critical evaluation parameter in the clinical cancer research and treatment evaluation programs. This study was carried out in a 1200 bed tertiary care teaching hospital, MGM Hospital, located at Warangal, India. Present study assessed the overall quality of life, symptoms of patients affected by breast, head and neck, cervical and stomach cancers by using guidelines and modules of The European Organisation for Research and Treatment of Cancer. The assessment was carried out in two phases, as review I at ≤2 cycles and review II at ≥5 cycles of treatment. Data were analyzed for 104 individuals with the mean age of 46.1±11.2 years. The evaluation was characterised as functional scale and symptom scale. In the functional scale physical, and role functions were significant (P<0.05) in all the 4 types of cancers studied. Additional, future perspective, social and emotional functions were observed to be significant in breast cancer, head and neck cancer and cervical cancer, respectively. Where as in symptom scale pain was observed to be significant for all cancers studied. Individually, breast cancer patient also showed significant parameters like fatigue, arm symptoms, and upset by hair loss. Head and neck cancer patients had insomnia and diarrhoea as additional significant symptom scale parameters. In cervical cancer patients, fatigue, insomnia, menopausal symptoms, and in stomach cancer patients, nausea and vomiting, dysphagia, reflex symptoms and eating restrictions were significantly affected. Most of the findings are similar to past studies in the respective type of cancer patients which shows that, quality of life was mostly influenced by the above mentioned factors and have some interesting implications for management and treatment of cancer.
在过去十年中，癌症患者的生活质量调查已成为临床癌症研究和治疗评估项目中的一个关键评估参数。本研究在位于印度瓦朗加尔的拥有1200张床位的三级护理教学医院——MGM医院开展。本研究采用欧洲癌症研究与治疗组织的指南和模块，评估了乳腺癌、头颈癌、宫颈癌和胃癌患者的总体生活质量及症状。评估分两个阶段进行，治疗≤2个周期时为回顾I，≥5个周期时为回顾II。对104名平均年龄为46.1±11.2岁的个体进行了数据分析。评估分为功能量表和症状量表。在功能量表中，在所研究的所有4种癌症类型中，身体功能和角色功能均具有显著性差异（P<0.05）。此外，未来展望、社会功能和情感功能分别在乳腺癌、头颈癌和宫颈癌中具有显著性差异。而在症状量表中，在所研究的所有癌症中疼痛均具有显著性差异。单独来看，乳腺癌患者还表现出疲劳、手臂症状和脱发困扰等显著参数。头颈癌患者的失眠和腹泻是额外的显著症状量表参数。在宫颈癌患者中，疲劳、失眠、更年期症状显著，而在胃癌患者中，恶心、呕吐、吞咽困难、反射症状和饮食限制受到显著影响。大多数研究结果与以往针对相应癌症类型患者的研究相似，这表明生活质量大多受上述因素影响，并且对癌症的管理和治疗具有一些有趣的启示。
