Department of Community Medicine, Ramaiah Medical College, Bengaluru, India.
Department of Epidemiology and Biostatistics, Kidwai Memorial Institute of Oncology, Bengaluru, India.
Asian Pac J Cancer Prev. 2022 Aug 1;23(8):2727-2733. doi: 10.31557/APJCP.2022.23.8.2727.
Cervical Cancer is the leading cause of morbidity and mortality in India. It affects the patient's, physical and psychological state which results in lower quality of life (QoL). Women with cervical cancer may require counselling and time to enable them to deal with the disease and its treatment. The present study aimed to determine the quality of life and its determinants among cervical cancer patients.
A cross-sectional study was undertaken from April 2017 to September 2017 in a regional cancer centre in South India. Cervical cancer patients (N= 210) with histological confirmation were interviewed at the hospital. European Organization of Research and Treatment of Cancer (EORTC) questionnaire core module, QLQ-C30 Version 3.0, and recommended scoring algorithm were used to measure and analyse QoL. The Association of socio-economic determinants on quality of life was evaluated using multiple logistic regression.
Among 210 cervical cancer patients enrolled, the majority 106 (50.5%) of women were between the age group 46 to 59 years and most, i.e. 167(63.0%) were not literate. The median score in the global health status was 50.0[IQR 33.3 - 66.7], 66.7[IQR 60.0 - 80.0] in physical functioning, and 83.3[IQR 66.7 - 83.3] in pain symptoms respectively which were poor compared to reference score of EORTC for all normal females and those with any cancer. The factors which were significantly associated with the GHS QoL score were the advanced stage of disease (OR:2.1, 95%CI: 1.1 - 3.9) and the age of the patients ≥60 years compared with ≤ 45 years (OR:18.4, 95%CI: 6.8 - 50.1).
Cervical cancer patients had poor global health status compared to the reference score for all females with any cancer and the normal females. Advanced stage of cancer and older age have a significant association with QoL.
在印度，宫颈癌是导致发病率和死亡率的主要原因。它影响患者的身体和心理状态，导致生活质量（QoL）下降。宫颈癌患者可能需要咨询和时间来处理疾病及其治疗。本研究旨在确定宫颈癌患者的生活质量及其决定因素。
本研究为 2017 年 4 月至 2017 年 9 月在印度南部一家地区癌症中心进行的横断面研究。在医院采访了组织学确诊的宫颈癌患者（N=210）。欧洲癌症研究与治疗组织（EORTC）问卷核心模块、QLQ-C30 第 3.0 版和推荐的评分算法用于测量和分析 QoL。使用多因素逻辑回归评估社会经济决定因素与生活质量的关联。
在纳入的 210 例宫颈癌患者中，大多数（50.5%）女性年龄在 46 至 59 岁之间，大多数（63.0%）未受过教育。总体健康状况的中位数评分为 50.0[IQR 33.3-66.7]，身体功能评分为 66.7[IQR 60.0-80.0]，疼痛症状评分为 83.3[IQR 66.7-83.3]，与 EORTC 所有正常女性和任何癌症患者的参考评分相比均较差。与 GHS QoL 评分显著相关的因素是疾病的晚期（OR：2.1，95%CI：1.1-3.9）和患者年龄≥60 岁（OR：18.4，95%CI：6.8-50.1）与≤45 岁相比。
与所有女性癌症患者和正常女性的参考评分相比，宫颈癌患者的总体健康状况较差。癌症的晚期和年龄较大与 QoL 有显著关联。
