Ratna Sunil B, Sampath Kumar T S, Chakkingal Uday, Nandakumar V, Doble Mukesh
Department of Metallurgical and Materials Engineering, Indian Institute of Technology Madras, Chennai 600036, India.
Department of Metallurgical and Materials Engineering, Indian Institute of Technology Madras, Chennai 600036, India.
Mater Sci Eng C Mater Biol Appl. 2014 Jun 1;39:315-24. doi: 10.1016/j.msec.2014.03.004. Epub 2014 Mar 12.
Nano-hydroxyapatite (nHA) reinforced magnesium composite (Mg-nHA) was fabricated by friction stir processing (FSP). The effect of smaller grain size and the presence of nHA particles on controlling the degradation of magnesium were investigated. Grain refinement from 1500μm to ≈3.5μm was observed after FSP. In vitro bioactivity studies by immersing the samples in supersaturated simulated body fluid (SBF 5×) indicate that the increased hydrophilicity and pronounced biomineralization are due to grain refinement and the presence of nHA in the composite respectively. Electrochemical test to assess the corrosion behavior also clearly showed the improved corrosion resistance due to grain refinement and enhanced biomineralization. Using MTT colorimetric assay, cytotoxicity study of the samples with rat skeletal muscle (L6) cells indicate marginal increase in cell viability of the FSP-Mg-nHA sample. The composite also showed good cell adhesion.
通过搅拌摩擦加工（FSP）制备了纳米羟基磷灰石（nHA）增强镁基复合材料（Mg-nHA）。研究了较小晶粒尺寸和nHA颗粒的存在对控制镁降解的影响。搅拌摩擦加工后观察到晶粒从1500μm细化至约3.5μm。通过将样品浸入过饱和模拟体液（SBF 5×）进行的体外生物活性研究表明，亲水性增加和明显的生物矿化分别归因于晶粒细化和复合材料中nHA的存在。评估腐蚀行为的电化学测试也清楚地表明，由于晶粒细化和生物矿化增强，耐腐蚀性得到改善。使用MTT比色法，对大鼠骨骼肌（L6）细胞进行样品的细胞毒性研究表明，FSP-Mg-nHA样品的细胞活力略有增加。该复合材料还表现出良好的细胞粘附性。
