Ponzo Valentina, Soldati Laura, Bo Simona
Department of Health Sciences, University of Milan, Milan, Italy.
J Transl Med. 2014 Jun 3;12:158. doi: 10.1186/1479-5876-12-158.
Resveratrol is a polyphenolic compound found in several plants. In the last decades, the interest in this compound has enormously increased after benefits on metabolism and increased lifespan of various organisms have been reported with its supplementation. Several in-vitro and animal studies have observed that resveratrol can act on multiple molecular targets, including sirtuins, a class of NAD+ -dependent deacetylases. Despite the enthusiastic results reported in many animal- and in-vitro studies, few trials have been performed in humans with contrasting results. These conflicting data may be due at least in part to differences in the characteristics of the patients enrolled, the dosages and the duration of supplementation. Furthermore, many questions remain still unsolved, such as the dose or the duration of treatment to maximize its effects, the bioavailability of resveratrol and the role of food matrix to improve its bioactivity.In conclusion, at present the use of resveratrol as a supplement is not yet justified by the existing evidence.
白藜芦醇是一种存在于多种植物中的多酚类化合物。在过去几十年里，随着补充白藜芦醇对各种生物体的新陈代谢有益且能延长寿命的报道出现，人们对这种化合物的兴趣大幅增加。多项体外和动物研究观察到，白藜芦醇可作用于多个分子靶点，包括一类依赖烟酰胺腺嘌呤二核苷酸（NAD+）的去乙酰化酶——沉默调节蛋白。尽管许多动物和体外研究报告了令人振奋的结果，但在人体上进行的试验很少，且结果相互矛盾。这些相互矛盾的数据可能至少部分归因于所纳入患者的特征、补充剂的剂量和持续时间的差异。此外，许多问题仍未解决，例如使白藜芦醇效果最大化的治疗剂量或持续时间、白藜芦醇的生物利用度以及食物基质对提高其生物活性的作用。总之，目前现有证据尚不足以证明将白藜芦醇用作补充剂是合理的。
