Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place Box 1057, New York, NY 10029, USA.
Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place Box 1057, New York, NY 10029, USA.
Environ Res. 2014 Aug;133:12-9. doi: 10.1016/j.envres.2014.04.040. Epub 2014 Jun 3.
Exposures of children to phthalates, parabens, and bisphenol-A (BPA) are of concern because of their hormonal potential. These agents are found in a wide range of foods and packaging. We investigated whether intake of certain foods predict exposures to these chemicals in young girls.
Among 1101 girls (6-8 years at enrollment) from the Breast Cancer and Environment Research Program (BCERP) study, we measured urinary exposure biomarkers for phthalates, parabens, and BPA and assessed dietary intake using 24-h recall 2-4 times. We examined the average daily servings of major and minor food groups categorized as 0 to <0.5, 0.5 to <1 and ≥ 1 servings per day. Items included dairy, eggs, fats, fish, fruit, single grains, meat, non-poultry meats, pasta, poultry and vegetables. Covariate-adjusted least squares geometric means and 95% confidence intervals of creatinine-corrected phthalate and phenol metabolite concentrations in urine were calculated in relation to food intake.
Grains, flour and dry mixes and total fish consumption were positively associated with BPA and the sum of four di-2-ethylhexylphthalate (DEHP) urinary metabolite concentrations. Non-fresh vegetables and poultry were both positively associated with BPA and paraben urinary concentrations. Fats, oils and poultry consumption were positively associated with BPA. Whole-fat dairy consumption was associated with ΣDEHP.
Some foods may contribute to child exposures to certain chemicals, and this may constitute modifiable means to reduce these environmental exposures.
儿童接触邻苯二甲酸酯、对羟基苯甲酸酯和双酚 A（BPA）令人担忧，因为这些物质具有潜在的激素活性。这些物质存在于各种食物和包装中。我们研究了某些食物的摄入量是否可以预测少女接触这些化学物质的情况。
在来自乳腺癌和环境研究计划（BCERP）的 1101 名女孩（入组时年龄为 6-8 岁）中，我们测量了尿液中邻苯二甲酸酯、对羟基苯甲酸酯和 BPA 的暴露生物标志物，并使用 24 小时回忆法评估了 2-4 次饮食摄入量。我们评估了每天食用的主要和次要食物组的平均份数，分为 0 至<0.5、0.5 至<1 和≥1 份/天。包括奶制品、鸡蛋、脂肪、鱼类、水果、单一谷物、肉类、非禽肉、面食、家禽和蔬菜。在调整协变量后，用尿中肌酐校正的邻苯二甲酸酯和酚代谢物浓度的最小二乘几何均数及其 95%置信区间与食物摄入量相关。
谷物、面粉和干混合物以及鱼类总摄入量与 BPA 和四种二（2-乙基己基）邻苯二甲酸（DEHP）尿代谢物浓度的总和呈正相关。非新鲜蔬菜和家禽与 BPA 和对羟基苯甲酸酯尿浓度均呈正相关。脂肪、油和家禽的摄入与 BPA 呈正相关。全脂乳制品的摄入量与ΣDEHP 呈正相关。
某些食物可能会导致儿童接触某些化学物质，这可能是减少这些环境暴露的可改变手段。
