创伤后应激障碍与血脂异常之间联系的行为健康调节因素。
Behavioral health mediators of the link between posttraumatic stress disorder and dyslipidemia.
作者信息
Dennis Paul A, Ulmer Christi S, Calhoun Patrick S, Sherwood Andrew, Watkins Lana L, Dennis Michelle F, Beckham Jean C
机构信息
Durham Veterans Affairs Medical Center, Durham, NC, 27705, USA.
Durham Veterans Affairs Medical Center, Durham, NC, 27705, USA; Veterans Affairs Center for Health Services Research in Primary Care, Durham, NC, 27705, USA; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA.
出版信息
J Psychosom Res. 2014 Jul;77(1):45-50. doi: 10.1016/j.jpsychores.2014.05.001. Epub 2014 May 14.
OBJECTIVES
Posttraumatic stress disorder (PTSD) has been linked to dyslipidemia, which is a major risk factor for coronary artery disease. Although this link is thought to reflect response to heightened stress, behavioral health risks, including smoking, alcohol dependence, and poor sleep quality, may mediate the relationship between PTSD and dyslipidemia.
METHODS
To test this hypothesis, serum lipid levels were collected from 220 young adults (18-39 years old), 103 of whom were diagnosed with PTSD.
RESULTS
PTSD and associated depressive symptoms were negatively related to high-density lipoprotein cholesterol (HDL-C), p=.04, and positively related to triglyceride (TG) levels, p=.04. Both associations were mediated by cigarette consumption and poor sleep quality, the latter of which accounted for 83% and 93% of the effect of PTSD and depression on HDL-C and TG, respectively.
CONCLUSIONS
These results complement recent findings highlighting the prominence of health behaviors in linking PTSD with cardiovascular risk.
目的
创伤后应激障碍（PTSD）与血脂异常有关，血脂异常是冠状动脉疾病的主要危险因素。尽管这种关联被认为反映了对压力增加的反应，但包括吸烟、酒精依赖和睡眠质量差在内的行为健康风险可能介导了PTSD与血脂异常之间的关系。
方法
为了验证这一假设，收集了220名年轻人（18 - 39岁）的血脂水平，其中103人被诊断为创伤后应激障碍。
结果
创伤后应激障碍及相关抑郁症状与高密度脂蛋白胆固醇（HDL-C）呈负相关，p = 0.04，与甘油三酯（TG）水平呈正相关，p = 0.04。这两种关联均由吸烟和睡眠质量差介导，后者分别占创伤后应激障碍和抑郁对HDL-C和TG影响的83%和93%。
结论
这些结果补充了最近的研究发现，突出了健康行为在将创伤后应激障碍与心血管风险联系起来方面的重要性。
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