Hoogerheide David P, Lu Bo, Golovchenko Jene A
Department of Physics and ‡School of Engineering and Applied Sciences, Harvard University , Cambridge, Massachusetts 02138, United States.
ACS Nano. 2014 Jul 22;8(7):7384-91. doi: 10.1021/nn5025829. Epub 2014 Jun 20.
We report the formation of a tunable single DNA molecule trap near a solid-state nanopore in an electrolyte solution under conditions where an electric force and a pressure-induced viscous flow force on the molecule are nearly balanced. Trapped molecules can enter the pore multiple times before escaping the trap by passing through the pore or by diffusing away. Statistical analysis of many individually trapped molecules yields a detailed picture of the fluctuation phenomena involved, which are successfully modeled by a one-dimensional first passage approach.
我们报道了在电解质溶液中，在分子上的电力和压力诱导的粘性流体力几乎平衡的条件下，在固态纳米孔附近形成了一个可调谐的单DNA分子阱。被捕获的分子在通过纳米孔或扩散离开从而逃离陷阱之前，可以多次进入纳米孔。对许多单独捕获的分子进行统计分析，得出了所涉及的波动现象的详细情况，这些现象通过一维首次通过方法成功建模。
