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可生物降解的弹性聚癸二酸甘油酯作为镍钛诺裸支架的涂层材料。

Biodegradable and elastomeric poly(glycerol sebacate) as a coating material for nitinol bare stent.

作者信息

Kim Min Ji, Hwang Moon Young, Kim JiHeung, Chung Dong June

机构信息

Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon 440746, Republic of Korea.

School of Chemical Engineering, Sungkyunkwan University, Suwon 440746, Republic of Korea.

出版信息

Biomed Res Int. 2014;2014:956952. doi: 10.1155/2014/956952. Epub 2014 May 13.

DOI:10.1155/2014/956952
PMID:24955369
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4052888/
Abstract

We synthesized and evaluated biodegradable and elastomeric polyesters (poly(glycerol sebacate) (PGS)) using polycondensation between glycerol and sebacic acid to form a cross-linked network structure without using exogenous catalysts. Synthesized materials possess good mechanical properties, elasticity, and surface erosion biodegradation behavior. The tensile strength of the PGS was as high as 0.28 ± 0.004 MPa, and Young's modulus was 0.122 ± 0.0003 MPa. Elongation was as high as 237.8 ± 0.64%, and repeated elongation behavior was also observed to at least three times the original length without rupture. The water-in-air contact angles of the PGS surfaces were about 60°. We also analyzed the properties of an electrospray coating of biodegradable PGS on a nitinol stent for the purpose of enhancing long-term patency for the therapeutic treatment of varicose veins disease. The surface morphology and thickness of coating layer could be controlled by adjusting the electrospraying conditions and solution parameters.

摘要

我们通过甘油和癸二酸之间的缩聚反应合成并评估了可生物降解的弹性聚酯（聚癸二酸甘油酯，PGS），以形成交联网络结构，且无需使用外源催化剂。合成材料具有良好的机械性能、弹性和表面侵蚀生物降解行为。PGS的拉伸强度高达0.28±0.004MPa，杨氏模量为0.122±0.0003MPa。伸长率高达237.8±0.64%，并且还观察到重复伸长行为至少达到原始长度的三倍而不破裂。PGS表面在空气中的水接触角约为60°。为了提高静脉曲张疾病治疗的长期通畅性，我们还分析了可生物降解的PGS在镍钛诺支架上的电喷雾涂层的性能。通过调整电喷雾条件和溶液参数，可以控制涂层的表面形态和厚度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/d80929c3ecae/BMRI2014-956952.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/5963a839a6c9/BMRI2014-956952.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/4f0eba490b29/BMRI2014-956952.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/e6f4c49331a6/BMRI2014-956952.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/2beb75ef1806/BMRI2014-956952.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/071e44e29e39/BMRI2014-956952.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/77a463ce3515/BMRI2014-956952.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/d80929c3ecae/BMRI2014-956952.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/5963a839a6c9/BMRI2014-956952.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/4f0eba490b29/BMRI2014-956952.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/e6f4c49331a6/BMRI2014-956952.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/2beb75ef1806/BMRI2014-956952.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/071e44e29e39/BMRI2014-956952.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/77a463ce3515/BMRI2014-956952.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9028/4052888/d80929c3ecae/BMRI2014-956952.007.jpg

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