人基因mRNA中miR-619-5p、miR-5095、miR-5096和miR-5585-3p结合位点的特性
The properties of binding sites of miR-619-5p, miR-5095, miR-5096, and miR-5585-3p in the mRNAs of human genes.
作者信息
Ivashchenko Anatoly, Berillo Olga, Pyrkova Anna, Niyazova Raigul, Atambayeva Shara
机构信息
National Nanotechnology Laboratory, Al-Farabi Kazakh National University, Almaty 050038, Kazakhstan.
出版信息
Biomed Res Int. 2014;2014:720715. doi: 10.1155/2014/720715. Epub 2014 Aug 4.
The binding of 2,578 human miRNAs with the mRNAs of 12,175 human genes was studied. It was established that miR-619-5p, miR-5095, miR-5096, and miR-5585-3p bind with high affinity to the mRNAs of the 1215, 832, 725, and 655 genes, respectively. These unique miRNAs have binding sites in the coding sequences and untranslated regions of mRNAs. The mRNAs of many genes have multiple miR-619-5p, miR-5095, miR-5096, and miR-5585-3p binding sites. Groups of mRNAs in which the ordering of the miR-619-5p, miR-5095, miR-5096, and miR-5585-3p binding sites differ were established. The possible functional and evolutional properties of unique miRNAs are discussed.
研究了2578种人类微小RNA（miRNA）与12175个人类基因的信使核糖核酸（mRNA）的结合情况。结果表明，miR-619-5p、miR-5095、miR-5096和miR-5585-3p分别与1215、832、725和655个基因的mRNA具有高亲和力结合。这些独特的miRNA在mRNA的编码序列和非翻译区具有结合位点。许多基因的mRNA具有多个miR-619-5p、miR-5095、miR-5096和miR-5585-3p结合位点。建立了miR-619-5p、miR-5095、miR-5096和miR-5585-3p结合位点顺序不同的mRNA组。讨论了独特miRNA可能的功能和进化特性。
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