Hasan Anwarul, Nurunnabi Md, Morshed Mahboob, Paul Arghya, Polini Alessandro, Kuila Tapas, Al Hariri Moustafa, Lee Yong-kyu, Jaffa Ayad A
Biomedical Engineering and Department of Mechanical Engineering, Faculty of Engineering and Architecture, American University of Beirut, Beirut 1107 2020, Lebanon ; Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA ; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical and Biological Engineering, Korea National University of Transportation, 50 Daehak-ro, Chungju 380-702, Republic of Korea.
Biomed Res Int. 2014;2014:307519. doi: 10.1155/2014/307519. Epub 2014 Aug 6.
Biosensors research is a fast growing field in which tens of thousands of papers have been published over the years, and the industry is now worth billions of dollars. The biosensor products have found their applications in numerous industries including food and beverages, agricultural, environmental, medical diagnostics, and pharmaceutical industries and many more. Even though numerous biosensors have been developed for detection of proteins, peptides, enzymes, and numerous other biomolecules for diverse applications, their applications in tissue engineering have remained limited. In recent years, there has been a growing interest in application of novel biosensors in cell culture and tissue engineering, for example, real-time detection of small molecules such as glucose, lactose, and H2O2 as well as serum proteins of large molecular size, such as albumin and alpha-fetoprotein, and inflammatory cytokines, such as IFN-g and TNF-α. In this review, we provide an overview of the recent advancements in biosensors for tissue engineering applications.
生物传感器研究是一个快速发展的领域，多年来已发表了数以万计的论文，该行业目前价值数十亿美元。生物传感器产品已在众多行业中得到应用，包括食品饮料、农业、环境、医学诊断和制药等行业，以及更多其他行业。尽管已经开发出了许多用于检测蛋白质、肽、酶和众多其他生物分子以用于各种应用的生物传感器，但其在组织工程中的应用仍然有限。近年来，人们对新型生物传感器在细胞培养和组织工程中的应用越来越感兴趣，例如实时检测小分子，如葡萄糖、乳糖和过氧化氢，以及大分子血清蛋白，如白蛋白和甲胎蛋白，还有炎性细胞因子，如干扰素-γ和肿瘤坏死因子-α。在本综述中，我们概述了用于组织工程应用的生物传感器的最新进展。
